Polystyrene Microplastics Affect the Reproductive Performance of Male Mice and Lipid Homeostasis in Their Offspring
Polystyrene Microplastics Affect the Reproductive Performance of Male Mice and Lipid Homeostasis in Their Offspring
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聚苯乙烯微塑料影响雄性小鼠的生殖性能及其后代的脂质稳态
DOI：
10.1021/acs.estlett.2c00262
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发表时间：
2022-08
影响因子：
10.9
通讯作者：
Da Chen
中科院分区：
文献类型：
--
作者：
Yongfeng Deng;Hexia Chen;Yichao Huang;Qing Wang;Wen Chen;Da Chen
微塑料（MP）对人类和其他哺乳动物的潜在健康风险已引起全球关注。然而，长期暴露于环境相关剂量的MP是否会损害哺乳动物的生殖功能并对其后代造成跨代影响仍不清楚。我们的研究表明，长期（即，21周）暴露于环境相关剂量的聚苯乙烯MP（40-100 μm）不仅显著降低了睾丸相对重量，而且降低了精子质量（即，精子数量减少，精子表型改变），从而影响雄性小鼠的生殖性能。暴露还通过改变23种脂质中的17种来失调F1后代的脂质代谢。特别是，三种脂质与非酒精性脂肪肝密切相关;即，在F1代后代的肝脏和血浆中，烷基磷脂酰胆碱、烯基磷脂酰胆碱和烯基磷脂酰乙醇胺的水平显著增加。脂质代谢破坏也表现出剂量、性别和组织特异性模式。我们的研究结果首次证明了暴露于环境相关剂量的MP对陆生哺乳动物的雄性生殖影响及其对后代的跨代影响的体内证据。
The potential health risks of microplastics (MPs) to humans and other mammals have attracted global attention. However, whether long-term exposure to environmentally relevant doses of MPs could impair the reproductive functions of mammals and cause transgenerational effects on their offspring remains largely unclear. Our study revealed that long-term (i.e., 21 weeks) exposure to environmentally relevant doses of polystyrene MPs (40–100 μm) not only significantly decreased testicle relative weight but also decreased sperm quality (i.e., decreased sperm number and changed sperm phenotype), thus affecting the reproductive performance of male mice. The exposure also dysregulated lipid metabolism in their F1 offspring by altering 17 of 23 lipid classes. In particular, three lipid classes were closely related to non-alcoholic fatty liver disease; i.e., levels of alkylphosphatidylcholine, alkenylphosphatidylcholine, and alkenylphosphatidylethanolamine were significantly increased in the liver and plasma of F1 offspring. The lipid metabolism disruption also exhibited a dose-, gender-, and tissue-specific pattern. Our findings demonstrate for the first time thein vivoevidence of the male reproductive effects of exposure to environmentally relevant doses of MPs on terrestrial mammals and transgenerational effects on their offspring.
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DOI：
10.21203/rs.3.rs-74078/v2
发表时间：
2020-11
影响因子：
3.1
作者：
Kazutoshi Hisano;S. Kawase;Tetsuhiko Mimura;Hironori Yoshida;H. Yamada;H. Haniu;T. Tsukahara;Taiga Kurihara;Y. Matsuda;N. Saito;Takeshi Uemura
通讯作者：
Kazutoshi Hisano;S. Kawase;Tetsuhiko Mimura;Hironori Yoshida;H. Yamada;H. Haniu;T. Tsukahara;Taiga Kurihara;Y. Matsuda;N. Saito;Takeshi Uemura
影响因子：
9.8
作者：
Landrigan, Philip J.;Fuller, Richard;Bose-O'Reilly, Stephan
通讯作者：
Bose-O'Reilly, Stephan
影响因子：
9.8
作者：
Yang, Yan;Sun, Fengjiang;Huang, Yichao
通讯作者：
Huang, Yichao
妊娠期和哺乳期母体聚苯乙烯微塑料暴露改变了母鼠及其 F1 和 F2 后代的代谢稳态
影响因子：
11.4
作者：
Luo, Ting;Wang, Caiyun;Jin, Yuanxiang
通讯作者：
Jin, Yuanxiang
影响因子：
11.4
作者：
Cox, Kieran D.;Covernton, Garth A.;Dudas, Sarah E.
通讯作者：
Dudas, Sarah E.