Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder.
Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder.
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DOI：
10.1111/bdi.12110
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发表时间：
2013-11
影响因子：
5.4
通讯作者：
Clementz BA
中科院分区：
文献类型：
--
作者：
Hamm JP;Ethridge LE;Shapiro JR;Pearlson GD;Tamminga CA;Sweeney JA;Keshavan MS;Thaker GK;Clementz BA
Bipolar I disorder is a disabling illness affecting 1% of people worldwide. Family and twin studies suggest that psychotic bipolar disorder (BDP) represents a homogenous subgroup with an etiology distinct from non-psychotic bipolar disorder (BDNP) and partially shared with schizophrenia. Studies of auditory electrophysiology [e.g., paired-stimulus and oddball measured with electroencephalography (EEG)] consistently report deviations in psychotic groups (schizophrenia, BDP), yet such studies comparing BDP and BDNP are sparse and, in some cases, conflicting. Auditory EEG responses are significantly reduced in unaffected relatives of psychosis patients, suggesting that they may relate to both psychosis liability and expression. While 64-sensor EEGs were recorded, age- and gender-matched samples of 70 BDP, 35 BDNP {20 with a family history of psychosis [BDNP(+)]}, and 70 psychiatrically healthy subjects were presented typical auditory paired-stimuli and auditory oddball paradigms. Oddball P3b reductions were present and indistinguishable across all patient groups. P2s to paired-stimuli were abnormal only in BDP and BDNP(+). Conversely, N1 reductions to stimuli in both paradigms and P3a reductions were present in both BDP and BDNP(−) groups but were absent in BDNP(+). While nearly all auditory neural response components studied were abnormal in BDP, BDNP abnormalities at early- and mid-latencies were moderated by family psychosis history. The relationship between psychosis expression, heritable psychosis risk, and neurophysiology within bipolar disorder, therefore, may be complex. Consideration of such clinical disease heterogeneity may be important for future investigations of the pathophysiology of major psychiatric disturbance.
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影响因子：
2.9
作者：
Frangou S
通讯作者：
Frangou S
影响因子：
4.7
作者：
Godey, B;Schwartz, D;Liégeois-Chauvel, C
通讯作者：
Liégeois-Chauvel, C
影响因子：
2
作者：
Clementz, BA;Blumenfeld, LD
通讯作者：
Blumenfeld, LD
影响因子：
10.4
作者：
Cox, LA
通讯作者：
Cox, LA
影响因子：
10.6
作者：
Ethridge, Lauren E.;Hamm, Jordan P.;Shapiro, John R.;Summerfelt, Ann T.;Keedy, Sarah K.;Stevens, Michael C.;Pearlson, Godfrey;Tamminga, Carol A.;Boutros, Nash N.;Sweeney, John A.;Keshavan, Matcheri S.;Thaker, Gunvant;Clementz, Brett A.
通讯作者：
Clementz, Brett A.