Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder.
Neural activations during auditory oddball processing discriminating schizophrenia and psychotic bipolar disorder.
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DOI：
10.1016/j.biopsych.2012.03.034
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发表时间：
2012-11-01
影响因子：
10.6
通讯作者：
Clementz, Brett A.
中科院分区：
文献类型：
--
作者：
Ethridge, Lauren E.;Hamm, Jordan P.;Shapiro, John R.;Summerfelt, Ann T.;Keedy, Sarah K.;Stevens, Michael C.;Pearlson, Godfrey;Tamminga, Carol A.;Boutros, Nash N.;Sweeney, John A.;Keshavan, Matcheri S.;Thaker, Gunvant;Clementz, Brett A.
听觉怪异任务中P300事件相关电位的振幅降低可能是精神分裂症（SZ）的特征，但也报道了双相情感障碍。考虑到双相障碍样本中精神病性和非精神病性患者的频繁合并，这些诊断之间的听觉处理异常的相似性是不确定的；异常可能仅限于精神病。此外，通常只使用选定传感器和单一时间点的脑反应潜伏期和幅度来表征神经反应。包括时空和时频分析在内的脑激活综合量化可以更好地识别不同精神障碍患者独特的听觉怪异反应。采用多传感器脑电图技术对60例SZ、60例双相I型精神病（BPP）和60例健康受试者(H)在听怪任务中的神经反应进行了比较。在评估各组神经反应电压和频率随时间的差异之前，使用主成分分析来减少多传感器数据。线性判别分析揭示了5个最能区分不同群体的变量：(i)对标准刺激的晚β活动；（ii）对目标的晚β / γ活动将BPP与其他群体区分开来；（iii）标准的中潜伏期θ / α活动和（iv） N2反应后期的目标相关电压将精神病组与H组区分开来；(v) N2早期靶相关电压区分BPP和H。尽管P300能显著区分精神病组和H组，但除上述变量外，P300并不能唯一区分其他组。没有变量能唯一区分SZ，这可能表明这项任务在研究精神病相关神经生理学和BPP方面的实用性。
Reduced amplitude of the P300 event-related potential in auditory oddball tasks may characterize schizophrenia (SZ), but is also reported in bipolar disorder. Similarity of auditory processing abnormalities between these diagnoses is uncertain given the frequent combination of both psychotic and nonpsychotic patients in bipolar samples; abnormalities may be restricted to psychosis. In addition, typically only latency and amplitude of brain responses at selected sensors and singular time-points are used to characterize neural responses. Comprehensive quantification of brain activations involving both spatio-temporal and time-frequency analyses could better identify unique auditory oddball responses among patients with different psychotic disorders. Sixty SZ, 60 bipolar I with psychosis (BPP), and 60 healthy subjects (H) were compared on neural responses during an auditory oddball task using multi-sensor electroencephalography. Principal components analysis was used to reduce multi-sensor data prior to evaluating group differences on voltage and frequency of neural responses over time. Linear discriminant analysis revealed five variables that best differentiated groups: (i) late beta activity to standard stimuli and (ii) late beta/gamma activity to targets discriminated BPP from other groups; (iii) mid-latency theta/alpha activity to standards and (iv) target-related voltage at the late N2 response discriminated both psychosis groups from H; and (v) target-related voltage during early N2 discriminated BPP from H. Although the P300 significantly differentiated psychotic groups from H, it did not uniquely discriminate groups beyond the above variables. No variable uniquely discriminated SZ, perhaps indicating utility of this task for studying psychosis-associated neurophysiology generally and BPP specifically.
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DOI：
10.1196/annals.1300.008
发表时间：
2003-01-01
期刊：
GLUTAMATE AND DISORDERS OF COGNITION AND MOTIVATION
影响因子：
--
作者：
Farber, NB
通讯作者：
Farber, NB
影响因子：
2
作者：
Clementz, BA;Blumenfeld, LD
通讯作者：
Blumenfeld, LD
影响因子：
4.5
作者：
Frangou, S;Sharma, T;Murray, RM
通讯作者：
Murray, RM
影响因子：
10.4
作者：
Cox, LA
通讯作者：
Cox, LA
影响因子：
10.6
作者：
Coburn, KL;Shillcutt, SD;Moore, NC
通讯作者：
Moore, NC