Latitude gradients for lymphoid neoplasm subtypes in Australia support an association with ultraviolet radiation exposure
Latitude gradients for lymphoid neoplasm subtypes in Australia support an association with ultraviolet radiation exposure
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澳大利亚淋巴肿瘤亚型的纬度梯度支持与紫外线辐射暴露之间的关联
DOI：
10.1002/ijc.28081
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发表时间：
2013
影响因子：
6.4
通讯作者：
C. Vajdic
中科院分区：
文献类型：
--
作者：
M. T. Leeuwen;J. Turner;M. Falster;N. S. Meagher;D. Joske;A. Grulich;G. Giles;C. Vajdic
考虑到围绕太阳紫外线辐射(UVR)暴露的不确定性和淋巴样肿瘤的风险，我们对2002至2006年间确诊的澳大利亚国家病例数据进行了生态分析。采用多元泊松回归方法，经性别、年龄组和历年调整后，用环境紫外线照射的替代指标--纬度带(<；29°S，29°S，≥37°S)检验各亚型的发病率。几种成熟的B细胞非霍奇金淋巴瘤的发病率随着距离赤道的距离而增加，包括弥漫性大B细胞[发病率比 = 1.37；95%可信区间：1.16-1.61，纬度≥37°S相对29°S]，淋巴浆细胞性(IRR = 1.34；95%CI：1.12-1.61)，粘膜相关淋巴组织(IRR = 1.32；95%CI：0.97-1.80)和套细胞淋巴瘤(IRR = 1.29；浆细胞瘤(IRR = 1.5 2；95%CI：1.0 9~2.11)；浆细胞骨髓瘤(IRR = 1.15；95%CI：1.0 3~1.2 7)。在几种成熟的皮肤T细胞肿瘤中也观察到了类似的模式，包括原发性皮肤间变性大细胞淋巴瘤(IRR = 4.26；95%CI：1.85-9.84)，真菌样/S综合征(IRR = 1.72；95%CI：1.2 0-2.46)，以及外周T细胞淋巴瘤(NOS)(IRR = 1.5 3；95%CI：1.17-2.00)。混合细胞/淋巴细胞耗竭(IRR = 1.6 0；95%CI：1.16~2.2 0)和结节硬化性霍奇金淋巴瘤(IRR = 1.5 7；95%CI：1.3 3~1.85)的发病率也随着距离赤道的距离而增加。这些亚型中的许多都与感染或免疫失调有关。我们的发现支持紫外线照射对几种淋巴肿瘤风险的可能保护作用，可能是通过在淋巴肿大中至关重要的维生素D相关免疫调节。
Given the uncertainty surrounding solar ultraviolet radiation (UVR) exposure and risk of lymphoid neoplasms, we performed an ecological analysis of national Australian data for incident cases diagnosed between 2002 and 2006. Subtype‐specific incidence was examined by latitude band (<29°S, 29–36°S, ≥37°S), a proxy for ambient UVR exposure, using multiple Poisson regression, adjusted for sex, age‐group and calendar year. Incidence increased with distance from the equator for several mature B‐cell non‐Hodgkin lymphomas, including diffuse large B‐cell [incidence rate ratio (IRR) = 1.37; 95% confidence interval (CI): 1.16–1.61 for latitude ≥37°S relative to <29°S], lymphoplasmacytic (IRR = 1.34; 95% CI: 1.12–1.61), mucosa‐associated lymphoid tissue (IRR = 1.32; 95% CI: 0.97–1.80) and mantle cell lymphoma (IRR = 1.29; 95% CI: 1.05–1.58), as well as plasmacytoma (IRR = 1.52; 95% CI: 1.09–2.11) and plasma cell myeloma (IRR = 1.15; 95% CI: 1.03–1.27). A similar pattern was observed for several mature cutaneous T‐cell neoplasms, including primary cutaneous anaplastic large cell lymphoma (IRR = 4.26; 95% CI: 1.85–9.84), mycosis fungoides/Sézary syndrome (IRR = 1.72; 95% CI: 1.20–2.46), and peripheral T‐cell lymphoma not otherwise specified (NOS) (IRR = 1.53; 95% CI: 1.17–2.00). Incidence of mixed cellularity/lymphocyte‐depleted (IRR = 1.60; 95% CI: 1.16–2.20) and nodular sclerosis Hodgkin lymphoma (IRR = 1.57; 95% CI: 1.33–1.85) also increased with distance from the equator. Many of these subtypes have a known association with infection or immune dysregulation. Our findings support a possible protective effect of UVR exposure on the risk of several lymphoid neoplasms, possibly through vitamin D‐related immune modulation critical in lymphomagenesis.
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影响因子：
20.3
作者：
Chang, Ellen T.;Canchola, Alison J.;Horn-Ross, Pamela L.
通讯作者：
Horn-Ross, Pamela L.
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
M. Purdue;D. Freedman;S. Gapstur;K. Helzlsouer;F. Laden;U. Lim;G. Maskarinec;N. Rothman;X. Shu;V. Stevens;A. Zeleniuch‐Jacquotte;D. Albanes;K. Bertrand;S. Weinstein;Kai Yu;Lonn Irish;R. Horst;Judith A. Hoffman-Bolton;E. Giovannucci;L. Kolonel;Kirk Snyder;W. Willett;A. Arslan;R. Hayes;W. Zheng;Y. Xiang;P. Hartge
通讯作者：
M. Purdue;D. Freedman;S. Gapstur;K. Helzlsouer;F. Laden;U. Lim;G. Maskarinec;N. Rothman;X. Shu;V. Stevens;A. Zeleniuch‐Jacquotte;D. Albanes;K. Bertrand;S. Weinstein;Kai Yu;Lonn Irish;R. Horst;Judith A. Hoffman-Bolton;E. Giovannucci;L. Kolonel;Kirk Snyder;W. Willett;A. Arslan;R. Hayes;W. Zheng;Y. Xiang;P. Hartge
影响因子：
45.3
作者：
Drake, Matthew T.;Maurer, Matthew J.;Cerhan, James R.
通讯作者：
Cerhan, James R.
影响因子：
20.3
作者：
Turner, Jennifer J.;Morton, Lindsay M.;Weisenburger, Dennis D.
通讯作者：
Weisenburger, Dennis D.
影响因子：
20.3
作者：
Shanafelt, Tait D.;Drake, Matthew T.;Cerhan, James R.
通讯作者：
Cerhan, James R.