The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task.
The cannabinoid CB(1) receptor antagonist CE prolongs spatial memory duration in a rat delayed radial arm maze memory task.
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大麻素 CB(1) 受体拮抗剂 CE 可延长大鼠延迟径向臂迷宫记忆任务的空间记忆持续时间。
DOI：
10.1016/j.ejphar.2008.06.049
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发表时间：
2008
影响因子：
5
通讯作者：
Lichtman,AronH
中科院分区：
文献类型：
--
作者：
Wise,LauraE;Iredale,PhilipA;Lichtman,AronH
大麻素受体系统在学习和记忆中起着不可或缺的作用。此外，大麻素CB1受体拮抗剂利莫那班已被发现可以改善各种动物记忆模型的表现。本研究测试了一种新的有效的大麻素CB1受体拮抗剂CE是否会延长空间记忆的持续时间。大鼠训练在一个两阶段的径向臂迷宫程序，包括收购和检索测试，这是分开的18小时的延迟。在采集阶段前30分钟、采集阶段后立即或检索测试前30分钟给予CE，以评估其对采集和检索过程的影响。行政长官前和收购阶段后立即显着减少检索测试期间犯的错误的数量。另一方面，CE管理30分钟前的检索测试没有影响的错误数量。这些研究结果表明，CE通过作用于巩固而不是检索过程来改善记忆，并进一步表明内源性大麻素系统在调节记忆持续时间方面具有重要作用。
The cannabinoid receptor system plays an integral role in learning and memory. Moreover, the cannabinoid CB1receptor antagonist rimonabant has been found to improve performance in a variety of animal memory models. The present study tested whether a novel and potent cannabinoid CB1receptor antagonist, CE, would prolong the duration of spatial memory. Rats were trained in a two-phase radial arm maze procedure, consisting of acquisition and retrieval tests, which were separated by an 18 h delay. CE was administered 30 min before the acquisition phase, immediately after the acquisition phase, or 30 min before the retrieval test to assess its effects on acquisition and retrieval processes. CE administered before and immediately after the acquisition phase significantly decreased the number of errors committed during the retrieval test. On the other hand, CE administered 30 min before the retrieval test had no effect on the number of errors committed. These findings demonstrate that CE improves memory by acting on consolidation, rather than retrieval, processes and further suggest that the endocannabinoid system has an important role in modulating memory duration.
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影响因子：
3.4
作者：
Mallet, PE;Beninger, RJ
通讯作者：
Beninger, RJ
影响因子：
5.1
作者：
Lutz, Beat
通讯作者：
Lutz, Beat
DOI：
--
发表时间：
1997-09
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
J. Brodkin;J. M. Moerschbaecher
通讯作者：
J. Brodkin;J. M. Moerschbaecher
影响因子：
4.7
作者：
Di Marzo, V;Berrendero, F;Fernández-Ruiz, JJ
通讯作者：
Fernández-Ruiz, JJ
影响因子：
5
作者：
Lichtman, AH
通讯作者：
Lichtman, AH