Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.
Interaction of basolateral amygdala, ventral hippocampus and medial prefrontal cortex regulates the consolidation and extinction of social fear.
复制标题
基底外侧杏仁核、腹侧海马和内侧前额叶皮层的相互作用调节社交恐惧的巩固和消除
DOI：
10.1186/s12993-018-0139-6
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发表时间：
2018-03-19
期刊：
影响因子：
--
通讯作者：
Jing YH
中科院分区：
文献类型：
--
作者：
Qi CC;Wang QJ;Ma XZ;Chen HC;Gao LP;Yin J;Jing YH
Following a social defeat, the balanced establishment and extinction of aversive information is a beneficial strategy for individual survival. Abnormal establishment or extinction is implicated in the development of mental disorders. This study investigated the time course of the establishment and extinction of aversive information from acute social defeat and the temporal responsiveness of the basolateral amygdala (BLA), ventral hippocampus (vHIP) and medial prefrontal cortex (mPFC) in this process. Mouse models of acute social defeat were established by using the resident–intruder paradigm. To evaluate the engram of social defeat, the intruder mice were placed into the novel context at designated time to test the social behavior. Furthermore, responses of BLA, vHIP and mPFC were investigated by analyzing the expression of immediate early genes, such as zif268, arc, and c-fos. The results showed after an aggressive attack, aversive memory was maintained for approximately 7 days before gradually diminishing. The establishment and maintenance of aversive stimulation were consistently accompanied by BLA activity. By contrast, vHIP and mPFC response was inhibited from this process. Additionally, injecting muscimol (Mus), a GABA receptor agonist, into the BLA alleviated the freezing behavior and social fear and avoidance. Simultaneously, Mus treatment decreased the zif268 and arc expression in BLA, but it increased their expression in vHIP. Our data support and extend earlier findings that implicate BLA, vHIP and mPFC in social defeat. The time courses of the establishment and extinction of social defeat are particularly consistent with the contrasting BLA and vHIP responses involved in this process. The online version of this article (10.1186/s12993-018-0139-6) contains supplementary material, which is available to authorized users.
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DOI：
10.1016/j.pnpbp.2003.09.012
发表时间：
2003-12-01
影响因子：
5.6
作者：
Blanchard, DC;Griebel, G;Blanchard, RJ
通讯作者：
Blanchard, RJ
影响因子：
6.6
作者：
Accolla, Ettore A.;Aust, Sabine;Draganski, Bogdan
通讯作者：
Draganski, Bogdan
中缝背核中 5-HT1A 自身受体的激活可减少社交失败的行为后果。
影响因子：
3.7
作者：
Cooper, Matthew A.;McIntyre, Kathleen E.;Huhman, Kim L.
通讯作者：
Huhman, Kim L.
DOI：
10.1523/jneurosci.6103-11.2013
发表时间：
2013-03-20
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Filiano AJ;Martens LH;Young AH;Warmus BA;Zhou P;Diaz-Ramirez G;Jiao J;Zhang Z;Huang EJ;Gao FB;Farese RV Jr;Roberson ED
通讯作者：
Roberson ED
主动避免学习需要前额叶抑制杏仁核介导的防御反应。
DOI：
10.1523/jneurosci.2596-12.2013
发表时间：
2013-02-27
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Moscarello JM;LeDoux JE
通讯作者：
LeDoux JE