Relationship between cognitive impairment and white-matter alteration in Parkinson's disease with dementia: tract-based spatial statistics and tract-specific analysis.
Relationship between cognitive impairment and white-matter alteration in Parkinson's disease with dementia: tract-based spatial statistics and tract-specific analysis.
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DOI：
10.1007/s00330-013-2775-4
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发表时间：
2013-07
影响因子：
5.9
通讯作者：
Hattori N
中科院分区：
文献类型：
--
作者：
Kamagata K;Motoi Y;Tomiyama H;Abe O;Ito K;Shimoji K;Suzuki M;Hori M;Nakanishi A;Sano T;Kuwatsuru R;Sasai K;Aoki S;Hattori N
我们利用扩散张量成像研究了帕金森病（PD）伴痴呆和不伴痴呆患者的白质改变与认知状态之间的关系。20例PD患者、20例PDD（帕金森病伴痴呆）患者和20例年龄匹配的健康对照者进行了扩散张量成像。采用基于轨迹的空间统计方法，将每个患者组的平均扩散率和各向异性分数（FA）图与对照组进行比较。生成胼胝体纤维束的纤维束成像图像，并测量平均扩散率和FA。PDD患者的许多主要神经束的FA值显著低于对照组; PDD患者的前额叶白色物质和胼胝体前额叶的FA值显著低于PD患者。帕金森病患者的简易精神状态检查量表（MMSE）评分与前额叶白色区FA值和胼胝体区FA值呈显著相关。我们的研究显示认知障碍与前额叶白色物质和胼胝体的改变之间的关系。这些变化可能有助于评估PD患者痴呆的发作。痴呆是帕金森病（PD）的一种常见且重要的非运动体征。PD痴呆的神经病理学基础尚不清楚。·弥散张量成像显示帕金森病痴呆患者前额叶白色物质异常。·前额叶白色物质改变可能是PD痴呆的有用生物标志物。
We investigated the relationship between white-matter alteration and cognitive status in Parkinson’s disease (PD) with and without dementia by using diffusion tensor imaging. Twenty PD patients, 20 PDD (Parkinson’s disease with dementia) patients and 20 age-matched healthy controls underwent diffusion tensor imaging. The mean diffusivity and fractional anisotropy (FA) map of each patient group were compared with those of the control group by using tract-based spatial statistics. Tractography images of the genu of the corpus callosum fibre tracts were generated, and mean diffusivity and FA were measured. FA values in many major tracts were significantly lower in PDD patients than in control subjects; in the prefrontal white matter and the genu of the corpus callosum they were significantly lower in PDD patients than in PD patients. There was a significant correlation between the Mini-Mental State Examination (MMSE) scores and the FA values of the prefrontal white matter and the genu of the corpus callosum in patients with PD. Our study shows a relationship between cognitive impairment and alteration of the prefrontal white matter and genu of the corpus callosum. These changes may be useful in assessing the onset of dementia in PD patients. • Dementia is a common and important non-motor sign of Parkinson’s disease (PD). • The neuropathological basis of dementia in PD is not clear. • DTI shows abnormalities in the prefrontal white matter in PD with dementia. • Prefrontal white matter alteration may be useful biomarker of dementia in PD.
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影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
2.5
作者：
Braak, H;Sandmann-Keil, D;Braak, E
通讯作者：
Braak, E
影响因子：
19.7
作者：
Hunsche, S;Moseley, ME;Hedehus, M
通讯作者：
Hedehus, M
影响因子：
9.9
作者：
Hurtig, HI;Trojanowski, JQ;Arnold, SE
通讯作者：
Arnold, SE
影响因子：
9.9
作者：
Braak, H;Rüb, U;de Vos, RAI
通讯作者：
de Vos, RAI