Insulin resistance and body fat distribution in South Asian men compared to Caucasian men.
Insulin resistance and body fat distribution in South Asian men compared to Caucasian men.
复制标题
与高加索男性相比，南亚男性的胰岛素抵抗和体内脂肪分布。
DOI：
10.1371/journal.pone.0000812
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发表时间：
2007-08-29
期刊：
影响因子：
3.7
通讯作者：
Abate, Nicola
中科院分区：
文献类型：
--
作者：
Chandalia, Manisha;Lin, Ping;Seenivasan, Thanalakshmi;Livingston, Edward H.;Snell, Peter G.;Grundy, Scott M.;Abate, Nicola
南亚人即使不肥胖也易患胰岛素抵抗。我们研究了南亚男性的体脂含量、分布和功能的特点，以及与高加索人相比与胰岛素抵抗的关系。29名南亚和18名高加索非糖尿病男性（年龄分别为27±3岁和27±3岁）接受了正常血糖-高胰岛素钳夹试验（用于胰岛素敏感性）、水下称重（用于全身脂肪）、全腹部MRI（用于腹腔内（IP）和皮下腹部（SA）脂肪）以及SA脂肪活检（用于脂肪细胞大小）。与白人相比，尽管BMI相似，但南亚人的总体脂较高（分别为体重的22±6和15±4%; p值<0.0001），SA脂肪较高（分别为3.5±1.9和2.2±1.3 kg; p值= 0.004），但IP脂肪无差异（分别为1.0±0.5和1.0±0.7 kg; p值= 0.4）。 南亚人的SA脂肪细胞大小显著更大（3491±1393和1648±864 µm2; p值= 0.0001），并且与葡萄糖处理率（r值=-0.57; p值= 0.0008）和血浆脂联素浓度（r值=-0.71; p值<0.0001）呈负相关。 即使SA在南亚人和高加索人之间匹配，脂肪细胞大小的差异仍然存在。即使IP脂肪量没有增加，也可以观察到年轻南亚男性的胰岛素抵抗，并且与大的SA脂肪细胞大小有关。因此，南亚人胰岛素抵抗的种族过剩似乎更多地与躯干脂肪过多和脂肪组织功能障碍有关，而不是与内脏脂肪过多有关。
South Asians are susceptible to insulin resistance even without obesity. We examined the characteristics of body fat content, distribution and function in South Asian men and their relationships to insulin resistance compared to Caucasians. Twenty-nine South Asian and 18 Caucasian non-diabetic men (age 27±3 and 27±3 years, respectively) underwent euglycemic-hyperinsulinemic clamp for insulin sensitivity, underwater weighing for total body fat, MRI of entire abdomen for intraperitoneal (IP) and subcutaneous abdominal (SA) fat and biopsy of SA fat for adipocyte size. Compared to Caucasians, in spite of similar BMI, South Asians had higher total body fat (22±6 and 15±4% of body weight; p-value<0.0001), higher SA fat (3.5±1.9 and 2.2±1.3 kg, respectively; p-value = 0.004), but no differences in IP fat (1.0±0.5 and 1.0±0.7 kg, respectively; p-value = 0.4). SA adipocyte cell size was significantly higher in South Asians (3491±1393 and 1648±864 µm2; p-value = 0.0001) and was inversely correlated with both glucose disposal rate (r-value = −0.57; p-value = 0.0008) and plasma adiponectin concentrations (r-value = −0.71; p-value<0.0001). Adipocyte size differences persisted even when SA was matched between South Asians and Caucasians. Insulin resistance in young South Asian men can be observed even without increase in IP fat mass and is related to large SA adipocytes size. Hence ethnic excess in insulin resistance in South Asians appears to be related more to excess truncal fat and dysfunctional adipose tissue than to excess visceral fat.
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影响因子：
4.2
作者：
Bajaj, Mandeep;Banerji, Mary Ann
通讯作者：
Banerji, Mary Ann
影响因子：
15.9
作者：
ABATE, N;GARG, A;GRUNDY, SM
通讯作者：
GRUNDY, SM
DOI：
10.1113/expphysiol.1962.sp001589
发表时间：
1962-01-01
影响因子：
--
作者：
THOMAS, LW
通讯作者：
THOMAS, LW
影响因子：
5.8
作者：
Abate, N;Chandalia, M;Grundy, SM
通讯作者：
Grundy, SM
影响因子：
8.2
作者：
Weyer, C;Foley, JE;Pratley, RE
通讯作者：
Pratley, RE