Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States.
Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States.
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DOI：
10.18632/aging.202591
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发表时间：
2021-02-11
期刊：
影响因子：
--
通讯作者：
Czeisler CA
中科院分区：
文献类型：
--
作者：
Robbins R;Quan SF;Weaver MD;Bormes G;Barger LK;Czeisler CA
背景：睡眠障碍和睡眠不足在老年人中很常见，并与痴呆和全因死亡率有关。使用全国代表性数据，我们研究了睡眠障碍和睡眠不足与老年人痴呆症发病风险和全因死亡率之间的关系。研究方法：国家健康和老龄化趋势研究（NHATS）是一项具有全国代表性的纵向研究，对象是美国65岁及以上的医疗保险受益人。在基线时进行评估睡眠障碍和持续时间的调查。我们使用考克斯比例风险模型，控制混杂因素，研究了睡眠障碍和睡眠不足与痴呆事件和全因死亡率之间的关系。结果如下：在调整后的考克斯模型中，在样本（n = 2，812）中，非常短的睡眠时间（≤5小时：HR = 2.04，95% CI：1.26 - 3.33）和睡眠潜伏期（>30分钟：HR = 1.45，95% CI：1.03 - 2.03）与痴呆事件相关。难以保持警觉（“某些天”：HR = 1.49，95% CI：1.13 - 1.94和“大多数/每天”：HR = 1.65，95% CI：1.17 - 2.32），午睡（“某些天”：HR = 1.38，95% CI：1.03 - 1.85;“大多数/每天”：HR = 1.73，95% CI：1.29 - 2.32），睡眠质量在校正的考克斯模型中，睡眠时间短（“差/极差”：HR = 1.75，95% CI：1.17 - 2.61）和睡眠时间短（≤5小时：HR = 2.38，95% CI：1.44 - 3.92）与全因死亡率相关。结论：解决睡眠障碍和睡眠不足可能对老年人痴呆症发病风险和全因死亡率产生积极影响。
Background: Sleep disturbance and deficiency are common among older adults and have been linked with dementia and all-cause mortality. Using nationally representative data, we examine the relationship between sleep disturbance and deficiency and their risk for incident dementia and all-cause mortality among older adults. Methods: The National Health and Aging Trends Study (NHATS) is a nationally-representative longitudinal study of Medicare beneficiaries in the US age 65 and older. Surveys that assessed sleep disturbance and duration were administered at baseline. We examined the relationship between sleep disturbance and deficiency and incident dementia and all-cause mortality over the following 5 years using Cox proportional hazards modeling, controlling for confounders. Results: Among the sample (n = 2,812), very short sleep duration (≤5 hours: HR = 2.04, 95% CI: 1.26 - 3.33) and sleep latency (>30 minutes: HR = 1.45, 95% CI: 1.03 - 2.03) were associated with incident dementia in adjusted Cox models. Difficulty maintaining alertness (“Some Days”: HR = 1.49, 95% CI: 1.13 - 1.94 and “Most/Every Day”: HR = 1.65, 95% CI: 1.17 - 2.32), napping (“Some days”: HR = 1.38, 95% CI: 1.03 - 1.85; “Most/Every Day”: HR = 1.73, 95% CI: 1.29 - 2.32), sleep quality (“Poor/Very Poor”: HR = 1.75, 95% CI: 1.17 - 2.61), and very short sleep duration (≤5 hours: HR = 2.38, 95% CI: 1.44 - 3.92) were associated with all-cause mortality in adjusted Cox models. Conclusions: Addressing sleep disturbance and deficiency may have a positive impact on risk for incident dementia and all-cause mortality among older adults.
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影响因子：
11.2
作者：
Lucey BP;Hicks TJ;McLeland JS;Toedebusch CD;Boyd J;Elbert DL;Patterson BW;Baty J;Morris JC;Ovod V;Mawuenyega KG;Bateman RJ
通讯作者：
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作者：
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影响因子：
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通讯作者：
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