Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds.
Cell survival and apoptosis signaling as therapeutic target for cancer: marine bioactive compounds.
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DOI：
10.3390/ijms14022334
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发表时间：
2013-01-24
影响因子：
5.6
通讯作者：
Se-Kwon K
中科院分区：
文献类型：
--
作者：
Kalimuthu S;Se-Kwon K
细胞凋亡的抑制导致细胞存活因子（例如，AKT）引起癌症中的持续细胞增殖。细胞凋亡是细胞自杀的主要形式，在多细胞生物体的各种生理过程和维持稳态中起着重要作用。许多发现已经阐明了细胞凋亡的分子机制，从而阐明了细胞凋亡和细胞存活因子之间的联系，这具有治疗效果。已显示抗癌剂诱导细胞凋亡和抑制细胞存活与肿瘤反应相关。细胞损伤通过诱导细胞凋亡、坏死和衰老诱导生长停滞和肿瘤抑制;细胞死亡的机制取决于暴露于各种抗癌剂后DNA损伤的程度。细胞凋亡主要受细胞存活和增殖信号分子的调控。作为一种新的治疗策略，替代类型的细胞死亡可能被利用来控制和根除癌细胞。这篇综述讨论了细胞凋亡和细胞存活的信号传导，以及海洋生物活性化合物的潜在贡献，表明可能会出现新的治疗策略。
Inhibition of apoptosis leads to activation of cell survival factors (e.g., AKT) causes continuous cell proliferation in cancer. Apoptosis, the major form of cellular suicide, is central to various physiological processes and the maintenance of homeostasis in multicellular organisms. A number of discoveries have clarified the molecular mechanism of apoptosis, thus clarifying the link between apoptosis and cell survival factors, which has a therapeutic outcome. Induction of apoptosis and inhibition of cell survival by anticancer agents has been shown to correlate with tumor response. Cellular damage induces growth arrest and tumor suppression by inducing apoptosis, necrosis and senescence; the mechanism of cell death depends on the magnitude of DNA damage following exposure to various anticancer agents. Apoptosis is mainly regulated by cell survival and proliferating signaling molecules. As a new therapeutic strategy, alternative types of cell death might be exploited to control and eradicate cancer cells. This review discusses the signaling of apoptosis and cell survival, as well as the potential contribution of marine bioactive compounds, suggesting that new therapeutic strategies might follow.
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