Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence.
Cathepsin W restrains peripheral regulatory T cells for mucosal immune quiescence.
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组织蛋白酶W限制外周调节T细胞以进行粘膜免疫静止。
DOI：
10.1126/sciadv.adf3924
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发表时间：
2023-07-14
期刊：
影响因子：
13.6
通讯作者：
Wu, Chuan
中科院分区：
文献类型：
--
作者：
Li, Jian;Chen, Zuojia;Kim, Girak;Luo, Jialie;Hori, Shohei;Wu, Chuan
Peripheral regulatory T (pTreg) cells are a key T cell lineage for mucosal immune tolerance and anti-inflammatory responses, and interleukin-2 receptor (IL-2R) signaling is critical for Treg cell generation, expansion, and maintenance. The expression of IL-2R on pTreg cells is tightly regulated to ensure proper induction and function of pTreg cells without a clear molecular mechanism. We here demonstrate that Cathepsin W (CTSW), a cysteine proteinase highly induced in pTreg cells under transforming growth factor–β stimulation is essential for the restraint of pTreg cell differentiation in an intrinsic manner. Loss of CTSW results in elevated pTreg cell generation, protecting the animals from intestinal inflammation. Mechanistically, CTSW inhibits IL-2R signaling in pTreg cells by cytosolic interaction with and process of CD25, repressing signal transducer and activator of transcription 5 activation to restrain pTreg cell generation and maintenance. Hence, our data indicate that CTSW acts as a gatekeeper to calibrate pTreg cell differentiation and function for mucosal immune quiescence. CTSW restrains pTreg cell differentiation and function for mucosal immune quiescence via inhibiting IL-2R signaling.
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影响因子：
64.8
作者：
Marson, Alexander;Kretschmer, Karsten;Young, Richard A.
通讯作者：
Young, Richard A.
IL-2 信号在适应性调节性 T 细胞两步分化过程中的动态双重作用
DOI：
10.4049/jimmunol.1200751
发表时间：
2013-04-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Guo Z;Khattar M;Schroder PM;Miyahara Y;Wang G;He X;Chen W;Stepkowski SM
通讯作者：
Stepkowski SM
控制FOXP3基因座中的顺式元素对调节T细胞身份的遗传控制。
影响因子：
64.5
作者：
Feng Y;Arvey A;Chinen T;van der Veeken J;Gasteiger G;Rudensky AY
通讯作者：
Rudensky AY
影响因子：
4.7
作者：
Chari R;Yeo NC;Chavez A;Church GM
通讯作者：
Church GM
影响因子：
8
作者：
Cho H;Jaime H;de Oliveira RP;Kang B;Spolski R;Vaziri T;Myers TG;Thovarai V;Shen Z;Fox JG;Leonard WJ;Kelsall BL
通讯作者：
Kelsall BL