New Corticopontine Connections in the Primate Brain: Contralateral Projections From the Arm/Hand Area of the Precentral Motor Region.
New Corticopontine Connections in the Primate Brain: Contralateral Projections From the Arm/Hand Area of the Precentral Motor Region.
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DOI：
10.3389/fnana.2018.00068
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发表时间：
2018
影响因子：
2.9
通讯作者：
Darling WG
中科院分区：
文献类型：
--
作者：
Morecraft RJ;Ge J;Stilwell-Morecraft KS;Rotella DL;Pizzimenti MA;Darling WG
同侧皮质桥脑投射（iCPP）代表终止于桥脑核（PN）的大量下行轴突系统。在灵长类动物中，这种投射以其通过经典的小脑环系统对侧上肢运动的主导影响而闻名。虽然一个更弱的对侧皮质桥脑投影（cCPP）从运动皮层到旁正中区已在非人灵长类动物的大脑中报道，我们提供了第一个全面的描述cCPP从外侧运动皮层使用高分辨率顺行追踪猕猴。我们发现初级运动皮层（M1）的手/手臂区域的cCPP相对较轻，腹外侧运动前皮层（LPMCv）的cCPP相对中等，背外侧运动前皮层（LPMCd）的cCPP更稳健且更广泛，涉及所有9个对侧PN。M1投影主要针对脑桥背侧区域，LPMCv投影针对脑桥内侧区域，LPMCd针对两个区域。这些结果表明，灵长类动物额动肌小脑投射的第一阶段是双侧的，并可能影响同侧和对侧肢体。临床上，起源于未受伤半球的cCPP可能会影响外侧皮质区单侧次全损伤后受累上肢的恢复过程。cCPP也可能导致单侧小脑损伤对侧上肢的轻度损伤。
The ipsilateral corticopontine projection (iCPP) represents a massive descending axon system terminating in the pontine nuclei (PN). In the primate, this projection is well known for its dominant influence on contralateral upper limb movements through the classical cerebrocerebellar circuity system. Although a much weaker contralateral corticopontine projection (cCPP) from motor cortex to the paramedian region has been reported in the non-human primate brain, we provide the first comprehensive description of the cCPP from the lateral motor cortex using high resolution anterograde tract tracing in Macaca mulatta. We found a relatively light cCPP from the hand/arm area of the primary motor cortex (M1), comparatively moderate cCPP from ventrolateral premotor cortex (LPMCv) and a more robust and widespread cCPP from the dorsolateral premotor cortex (LPMCd) that involved all nine contralateral PN. The M1 projection primarily targeted the dorsal pontine region, the LPMCv projection targeted the medial pontine region and LPMCd targeted both regions. These results show the first stage of the primate frontomotor cerebrocerebellar projection is bilateral, and may affect both ipsilateral and contralateral limbs. Clinically, the cCPP originating in the non-injured hemisphere may influence the recovery process of the more affected upper extremity following subtotal unilateral damage to the lateral cortical region. The cCPP may also contribute to the mild impairment of the upper limb contralateral to a unilateral cerebellar injury.
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影响因子：
2
作者：
Anens, Elisabeth;Kristensen, Bo;Hager-Ross, Charlotte
通讯作者：
Hager-Ross, Charlotte
影响因子：
4.3
作者：
Leergaard, Trygve B.;Bjaalie, Jan G.
通讯作者：
Bjaalie, Jan G.
影响因子：
2.5
作者：
GLICKSTEIN, M;MAY, JG;MERCIER, BE
通讯作者：
MERCIER, BE
影响因子：
3
作者：
CONDE, F
通讯作者：
CONDE, F
影响因子：
11.2
作者：
CHOLLET, F;DIPIERO, V;FRACKOWIAK, RSJ
通讯作者：
FRACKOWIAK, RSJ