Topography of the complete corticopontine projection: from experiments to principal Maps.
Topography of the complete corticopontine projection: from experiments to principal Maps.
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DOI：
10.3389/neuro.01.1.1.016.2007
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发表时间：
2007-11
影响因子：
4.3
通讯作者：
Bjaalie, Jan G.
中科院分区：
文献类型：
--
作者：
Leergaard, Trygve B.;Bjaalie, Jan G.
哺乳动物大脑的特点是其细胞成分的有序空间分布，通常被称为地形组织。皮层和皮层下地图的地形被认为代表功能或计算性质。在本研究中，我们研究了从大脑皮层到脑桥核的映射转换和组织原理，重点是大脑皮层作为一个整体映射到脑桥核上。在不同皮质区域注射单次或多次轴突示踪剂后，绘制了桥核内顺行标记轴突的三维分布图。所有三维重建数据集被归一化为桥核的标准化局部坐标系统，并上传到数据库应用程序（FACCS，脑-小脑系统功能解剖，可通过the啮齿动物大脑工作台获得）。数据库应用程序允许以新的组合灵活地使用数据，并使用以前发布的数据集。使用不同数据组合的可视化来探索组织的替代原则。作为这些分析的结果，开发了皮质高架投影的主要地形图。这张图遵循了大脑皮层和脑桥核中出现的早期时空梯度的组织。有了皮质桥突投影的主图，可以对大脑皮层中任何起源部位的脑桥靶区进行相当准确的预测。地图和底层共享数据集代表了该系统中地形组织和结构-功能关系建模的基础。
The mammalian brain is characterized by orderly spatial distribution of its cellular components, commonly referred to as topographical organization. The topography of cortical and subcortical maps is thought to represent functional or computational properties. In the present investigation, we have studied map transformations and organizing principles in the projections from the cerebral cortex to the pontine nuclei, with emphasis on the mapping of the cortex as a whole onto the pontine nuclei. Following single or multiple axonal tracer injections into different cortical regions, three-dimensional (3-D) distributions of anterogradely labeled axons in the pontine nuclei were mapped. All 3-D reconstructed data sets were normalized to a standardized local coordinate system for the pontine nuclei and uploaded in a database application (FACCS, Functional Anatomy of the Cerebro-Cerebellar System, available via The Rodent Brain Workbench, ). The database application allowed flexible use of the data in novel combinations, and use of a previously published data sets. Visualization of different combinations of data was used to explore alternative principles of organization. As a result of these analyses, a principal map of the topography of corticopontine projections was developed. This map followed the organization of early spatiotemporal gradients present in the cerebral cortex and the pontine nuclei. With the principal map for corticopontine projections, a fairly accurate prediction of pontine target area can be made for any site of origin in the cerebral cortex. The map and the underlying shared data sets represent a basis for modeling of topographical organization and structure–function relationships in this system.
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影响因子：
2.2
作者：
Bjaalie, JG;Leergaard, TB;Pettersen, C
通讯作者：
Pettersen, C
影响因子：
3.3
作者：
Bjaalie, JG;Leergaard, TB;Darin, D
通讯作者：
Darin, D
影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
DOI：
10.1101/sqb.1983.048.01.062
发表时间：
1983-01-01
期刊：
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY
影响因子：
--
作者：
BENTLEY, D;CAUDY, M
通讯作者：
CAUDY, M
影响因子：
3.7
作者：
ERZURUMLU, RS;JHAVERI, S
通讯作者：
JHAVERI, S