Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
Genetic diversity and variation in antimicrobial-resistance determinants of non-serotype 2 Streptococcus suis isolates from healthy pigs.
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DOI：
10.1099/mgen.0.000882
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发表时间：
2022-11
影响因子：
3.9
通讯作者：
Ben Pascoe
中科院分区：
文献类型：
--
作者：
Kittiwan, Nattinee;Calland, Jessica K.;Mourkas, Evangelos;Hitchings, Matthew D.;Murray, Susan;Tadee, Pakpoom;Tadee, Phacharaporn;Duangsonk, Kwanjit;Meric, Guillaume;Sheppard, Samuel K.;Patchanee, Prapas;Ben Pascoe
猪链球菌 是东南亚细菌性脑膜炎的主要原因，与猪密切接触后，人畜共患疾病频繁传播给人。少数入侵谱系是养猪业中地方性感染的原因，造成了相当大的全球经济损失。缺乏监测和临床治疗失败的上升趋势引起了人们对侵袭性肿瘤患者日益增长的抗菌药物耐药性（AMR）的担忧。 S.猪。健康和疾病分离株之间的基因流知之甚少，在这项研究中，我们的样本和序列收集的分离株主要来自健康的猪在清迈省，北方泰国。泛基因组特征鉴定了来自健康猪的分离株中广泛的遗传多样性和频繁的AMR携带。鉴定出多种AMR基因，赋予对氨基糖苷类、林可酰胺类、四环素类和大环内酯类的耐药性。所有分离株均对三种或三种以上不同的抗菌剂类别不敏感，75%的非血清2型分离株对六种或六种以上类别不敏感（而血清2型分离株为37.5%）。 AMR基因被发现的整合和接合元件先前在其他物种中观察到，这表明一个移动的基因库，可以访问的侵袭性疾病分离株。本文包含由Microreact托管的数据。
Streptococcus suis is a leading cause of bacterial meningitis in South-East Asia, with frequent zoonotic transfer to humans associated with close contact with pigs. A small number of invasive lineages are responsible for endemic infection in the swine industry, causing considerable global economic losses. A lack of surveillance and a rising trend in clinical treatment failure has raised concerns of growing antimicrobial resistance (AMR) among invasive S. suis . Gene flow between healthy and disease isolates is poorly understood and, in this study, we sample and sequence a collection of isolates predominantly from healthy pigs in Chiang Mai province, Northern Thailand. Pangenome characterization identified extensive genetic diversity and frequent AMR carriage in isolates from healthy pigs. Multiple AMR genes were identified, conferring resistance to aminoglycosides, lincosamides, tetracycline and macrolides. All isolates were non-susceptible to three or more different antimicrobial classes, and 75 % of non-serotype 2 isolates were non-susceptible to six or more classes (compared to 37.5 % of serotype 2 isolates). AMR genes were found on integrative and conjugative elements previously observed in other species, suggesting a mobile gene pool that can be accessed by invasive disease isolates. This article contains data hosted by Microreact.
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影响因子：
5.2
作者：
Delannoy S;Le Devendec L;Jouy E;Fach P;Drider D;Kempf I
通讯作者：
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DOI：
10.1038/ismej.2015.149
发表时间：
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期刊：
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10.1007/s10096-016-2616-x
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期刊：
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影响因子：
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作者：
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DOI：
10.1093/jac/dkaa345
发表时间：
2020-12-01
期刊：
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影响因子：
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作者：
Bortolaia V;Kaas RS;Ruppe E;Roberts MC;Schwarz S;Cattoir V;Philippon A;Allesoe RL;Rebelo AR;Florensa AF;Fagelhauer L;Chakraborty T;Neumann B;Werner G;Bender JK;Stingl K;Nguyen M;Coppens J;Xavier BB;Malhotra-Kumar S;Westh H;Pinholt M;Anjum MF;Duggett NA;Kempf I;Nykäsenoja S;Olkkola S;Wieczorek K;Amaro A;Clemente L;Mossong J;Losch S;Ragimbeau C;Lund O;Aarestrup FM
通讯作者：
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