The value of anti-Mullerian hormone measurement in the long GnRH agonist protocol: association with ovarian response and gonadotrophin-dose adjustments.
The value of anti-Mullerian hormone measurement in the long GnRH agonist protocol: association with ovarian response and gonadotrophin-dose adjustments.
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DOI：
10.1093/humrep/des101
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发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Arce JC
中科院分区：
文献类型：
--
作者：
Anckaert E;Smitz J;Schiettecatte J;Klein BM;Arce JC
本研究评估了血清和卵泡液（FF）抗<s:1>勒氏杆菌激素（AMH）浓度对体外受精周期治疗结果变量的预测价值。回顾性分析了731名促性腺功能正常的妇女的数据，这些妇女在长期使用GnRH激动剂方案后，在接受高纯度的促性腺激素（HP-hMG）或rFSH刺激后接受控制卵巢刺激。在两个治疗组,血清抗苗勒氏管激素浓度的刺激明显(P < 0.001)和血清雌二醇水平呈正相关(HP-hMG: r = 0.45; rFSH: r = 0.55),雄烯二酮(HP-hMG: r = 0.50; rFSH: 0.49)和总睾酮(HP-hMG: r = 0.40; rFSH: r = 0.36)结束时检索的刺激以及卵母细胞的数量(HP-hMG: r = 0.48; rFSH: r = 0.62),抗苗勒氏管激素的浓度在FF (HP-hMG: r = 0.55;取卵时血清孕酮浓度（HP-hMG: r = 0.39; rFSH: r = 0.50）。对于两种治疗，刺激开始时的血清AMH是刺激第6天需要增加或减少促性腺激素剂量以及卵巢反应低于（<7个卵母细胞）或高于（bbb15个卵母细胞）目标的良好预测指标。血清AMH与胚胎质量或持续妊娠之间无显著关系。长期方案中GnRH激动剂下调的IVF患者刺激开始时血清AMH浓度显示卵巢对促性腺激素的反应在卵母细胞回收和伴随的内分泌反应方面呈正相关。对于起始剂量固定的患者，AMH可以很好地预测刺激第6天是否需要调整促性腺激素剂量，但对个体患者的胚胎质量和妊娠机会的预测能力较差。
This study evaluated the predictive value of serum and follicular fluid (FF) concentrations of anti-Müllerian hormone (AMH) with respect to treatment outcome variables in an IVF cycle. A retrospective analysis was performed with data from 731 normogonadotrophic women undergoing controlled ovarian stimulation after stimulation with highly purified menotrophin (HP-hMG) or rFSH following a long GnRH agonist protocol. In both treatment groups, the serum AMH concentration at the start of the stimulation was significantly (P < 0.001) positively correlated with the serum levels of estradiol (HP-hMG: r = 0.45; rFSH: r = 0.55), androstenedione (HP-hMG: r = 0.50; rFSH: 0.49) and total testosterone (HP-hMG: r = 0.40; rFSH: r = 0.36) at the end of the stimulation as well as the number of oocytes retrieved (HP-hMG: r = 0.48; rFSH: r = 0.62), the AMH concentration in FF (HP-hMG: r = 0.55; rFSH: 0.61) and the serum progesterone concentration (HP-hMG: r = 0.39; rFSH: r = 0.50) at oocyte retrieval. For both treatments, serum AMH at the start of the stimulation was a good predictor of the need to increase or decrease the gonadotrophin dose on stimulation day 6 and of ovarian response below (<7 oocytes) or above (>15 oocytes) the target. No significant relationships were observed between serum AMH and embryo quality or ongoing pregnancy. The serum AMH concentration at the start of the stimulation in IVF patients down-regulated with GnRH agonist in the long protocol revealed a positive relationship with ovarian response to gonadotrophins in terms of oocytes retrieved and accompanying endocrine response. AMH is a good predictor of the need for gonadotrophin-dose adjustment on stimulation day 6 for patients with a fixed starting dose, but a poor predictor of embryo quality and pregnancy chances in individual patients.
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影响因子：
6.1
作者：
Carlsson, I. B.;Scott, J. E.;Hovatta, O.
通讯作者：
Hovatta, O.
影响因子：
4
作者：
Fong, S. Lie;Baart, E. B.;Laven, J. S. E.
通讯作者：
Laven, J. S. E.
影响因子：
6.7
作者：
Kwee, Janet;Schats, Roel;Lambalk, Cornelis
通讯作者：
Lambalk, Cornelis
影响因子：
6.1
作者：
Fanchin, R;Taieb, J;Bouyer, J
通讯作者：
Bouyer, J
影响因子：
6.7
作者：
de Vet, A;Laven, JSE;Fauser, BCJM
通讯作者：
Fauser, BCJM