Microbiota in allergy and asthma and the emerging relationship with the gut microbiome.
Microbiota in allergy and asthma and the emerging relationship with the gut microbiome.
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DOI：
10.1016/j.chom.2015.04.007
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发表时间：
2015-05-13
影响因子：
30.3
通讯作者：
Lynch SV
中科院分区：
文献类型：
--
作者：
Fujimura KE;Lynch SV
哮喘和特应性疾病是世界上最常见的慢性疾病之一，通常与适应性免疫的辅助性T - 2 （Th2）臂的过度激活有关。新出现的证据将特应性和哮喘与人类微生物组的组成和功能联系起来，微生物组是居住在人体内外并与人体相互作用的微生物的集合。研究人类宿主微生物生态的能力在很大程度上要归功于最近的技术发展，这些技术允许使用与培养无关的分子检测技术鉴定微生物及其产物。在这篇综述中，我们探讨了呼吸，肠道和环境微生物组在哮喘和过敏性疾病的发展，表现和衰减中的作用。尽管这仍是一个相对新兴的研究领域，但迄今为止的证据表明，气道和/或肠道微生物组可能是预防或治疗过敏性哮喘和其他以适应性免疫功能障碍为突出特征的疾病的有利靶点。
Asthma and atopy, classically associated with hyper-activation of the T helper 2 (Th2) arm of adaptive immunity, are amongst the most common chronic illnesses worldwide. Emerging evidence relates atopy and asthma to the composition and function of the human microbiome, the collection of microbes that reside in and on and interact with the human body. The ability to interrogate microbial ecology of the human host is due in large part to recent technological developments that permit identification of microbes and their products using culture-independent molecular detection techniques. In this review we explore the roles of respiratory, gut and environmental microbiomes in asthma and allergic disease development, manifestation and attenuation. Though still a relatively nascent field of research, evidence to date suggests that the airway and/or gut microbiome may represent fertile targets for prevention or management of allergic asthma and other diseases in which adaptive immune dysfunction is a prominent feature.
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影响因子：
30.3
作者：
Cahenzli J;Köller Y;Wyss M;Geuking MB;McCoy KD
通讯作者：
McCoy KD
影响因子：
3.7
作者：
Claesson MJ;O'Sullivan O;Wang Q;Nikkilä J;Marchesi JR;Smidt H;de Vos WM;Ross RP;O'Toole PW
通讯作者：
O'Toole PW
DOI：
10.1126/science.1198469
发表时间：
2011-01-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Atarashi K;Tanoue T;Shima T;Imaoka A;Kuwahara T;Momose Y;Cheng G;Yamasaki S;Saito T;Ohba Y;Taniguchi T;Takeda K;Hori S;Ivanov II;Umesaki Y;Itoh K;Honda K
通讯作者：
Honda K
影响因子：
3.7
作者：
Aagaard K;Riehle K;Ma J;Segata N;Mistretta TA;Coarfa C;Raza S;Rosenbaum S;Van den Veyver I;Milosavljevic A;Gevers D;Huttenhower C;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
64.5
作者：
Brodin P;Jojic V;Gao T;Bhattacharya S;Angel CJ;Furman D;Shen-Orr S;Dekker CL;Swan GE;Butte AJ;Maecker HT;Davis MM
通讯作者：
Davis MM