Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma.
Bioinformatics Analysis Discovers Microtubular Tubulin Beta 6 Class V (TUBB6) as a Potential Therapeutic Target in Glioblastoma.
复制标题
生物信息学分析发现微管微管蛋白 Beta 6 V 类 (TUBB6) 作为胶质母细胞瘤的潜在治疗靶点
DOI：
10.3389/fgene.2020.566579
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发表时间：
2020
影响因子：
3.7
通讯作者：
Lv K
中科院分区：
文献类型：
--
作者：
Jiang L;Zhu X;Yang H;Chen T;Lv K
胶质母细胞瘤（GBM）长期以来一直是科学家面临的主要临床研究挑战。线粒体相关基因家族在促进GBM肿瘤发生中的关键作用尚不清楚。我们检测到微管蛋白β 6 V类（TUBB 6）是GBM中33个差异表达的肿瘤聚焦基因（DEMFG）之一，并认为TUBB 6是GBM中潜在的治疗靶点。TUBB 6是GBM的重要基因，是原发性GBM的关键预后基因。GBM中TUBB 6突变罕见。仅四种TUBB 6共表达的枢纽基因（ANXA 2、S100 A11、FLNA和MSN）在较高表达组中表现出较差的总体存活率（p值< 0.05）。我们已经证实了TUBB 6及其伙伴ANXA 2和S100 A11在GBM中的上调，并验证了它们作为原发性GBM预后因素的重要性。TUBB 6与GBM样品中的基质评分显著相关（p值= 6.99E-04）。本研究旨在通过分析TUBB 6在人类原发性GBM癌中的表达、潜在功能和预后影响来评估新型枢纽基因的重要性。
Glioblastoma (GBM) has long been a major clinical research challenge to scientists. The pivotal role of the mitochondria related gene family in the promotion of GBM tumorigenesis is not clear. We detected that microtubular tubulin beta 6 class V (TUBB6) was one of 33 differentially expressed mitochondrial-focused genes (DEMFGs) in GBM, and considered that TUBB6 is a potential therapeutic target in GBM. TUBB6 was vital for GBM and marked as the key prognostic gene in primary GBM. Mutations of TUBB6 in GBM were rare. Only four TUBB6 co-expressed hub genes (ANXA2, S100A11, FLNA, and MSN) exhibited poorer overall survival rates in higher expression groups (p-value < 0.05). We have confirmed the up-regulation of TUBB6 and its partners, ANXA2 and S100A11 in GBM and validated their importance as prognostic factors in primary GBM. TUBB6 was significantly correlated with stromal score in GBM samples (p-value = 6.99E-04). This study aimed to assess the importance of novel hub genes by analyzing the expression, potential function and prognostic impact of TUBB6 in human primary GBM cancer.
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影响因子：
4.6
作者：
Arita H;Kinoshita M;Kawaguchi A;Takahashi M;Narita Y;Terakawa Y;Tsuyuguchi N;Okita Y;Nonaka M;Moriuchi S;Takagaki M;Fujimoto Y;Fukai J;Izumoto S;Ishibashi K;Nakajima Y;Shofuda T;Kanematsu D;Yoshioka E;Kodama Y;Mano M;Mori K;Ichimura K;Kanemura Y
通讯作者：
Kanemura Y
影响因子：
5.8
作者：
Liberzon, Arthur;Subramanian, Aravind;Mesirov, Jill P.
通讯作者：
Mesirov, Jill P.
在硅基因表达分析中，揭示了IDH1野生型神经胶质瘤，乳酸和乳酸和谷氨酸胶质酸胶质瘤的糖酵解和乙酸酯的溶无体病。
影响因子：
--
作者：
Khurshed M;Molenaar RJ;Lenting K;Leenders WP;van Noorden CJF
通讯作者：
van Noorden CJF
DOI：
10.1093/bioinformatics/btp101
发表时间：
2009-04-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Bindea G;Mlecnik B;Hackl H;Charoentong P;Tosolini M;Kirilovsky A;Fridman WH;Pagès F;Trajanoski Z;Galon J
通讯作者：
Galon J
影响因子：
14.9
作者：
Kutmon M;Riutta A;Nunes N;Hanspers K;Willighagen EL;Bohler A;Mélius J;Waagmeester A;Sinha SR;Miller R;Coort SL;Cirillo E;Smeets B;Evelo CT;Pico AR
通讯作者：
Pico AR