Basal ganglia volume and shape in children with attention deficit hyperactivity disorder.
Basal ganglia volume and shape in children with attention deficit hyperactivity disorder.
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DOI：
10.1176/appi.ajp.2008.08030426
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Mostofsky SH
中科院分区：
文献类型：
--
作者：
Qiu A;Crocetti D;Adler M;Mahone EM;Denckla MB;Miller MI;Mostofsky SH
基底神经节的体积异常与注意缺陷多动障碍（ADHD）有关，尤其是在男孩中。要指定这些异常的本地化，大变形几何形态度量映射（LDDMM）被用来检查ADHD，性别，以及它们之间的相互作用对基底神经节形状的影响。基底神经节（尾状核，壳核，苍白球）手动划定的磁共振成像从66个典型的发展中国家的儿童（35名男孩）和47名儿童（27名男孩）多动症。来自35个典型发育儿童的LDDMM映射用于生成基底神经节模板。使用模板坐标中的Laplace-Beltrami基函数，将每个受试者的每个结构相对于模板的形状变化建模为随机场。线性回归用于研究基底神经节体积和形状的组间差异。ADHD男孩的基底神经节体积明显小于正常发育男孩，LDDMM显示各组基底神经节形状显著不同。在尾状核头部和身体和前壳核以及左前苍白球和右腹侧壳核中观察到双侧体积压缩。体积扩张在后壳核最为明显。在ADHD女孩中没有发现体积或形状的差异。ADHD男孩基底神经节的形状压缩模式表明，ADHD相关的偏离典型的大脑发育涉及多个额叶皮层下控制回路，包括运动前区、眼神经和前额叶皮层回路。采用脑行为分析的进一步研究将有助于辨别这些回路对ADHD特征性反应控制受损的任务依赖性贡献。
Volumetric abnormalities of basal ganglia have been associated with attention deficit hyperactivity disorder (ADHD), especially in boys. To specify localization of these abnormalities, large deformation diffeomorphic metric mapping (LDDMM) was used to examine the effects of ADHD, sex, and their interaction on basal ganglia shapes. The basal ganglia (caudate, putamen, globus pallidus) were manually delineated on magnetic resonance imaging from 66 typically developing children (35 boys) and 47 children (27 boys) with ADHD. LDDMM mappings from 35 typically developing children were used to generate basal ganglia templates. Shape variations of each structure relative to the template were modeled for each subject as a random field using Laplace-Beltrami basis functions in the template coordinates. Linear regression was used to examine group differences in volumes and shapes of the basal ganglia. Boys with ADHD showed significantly smaller basal ganglia volumes compared with typically developing boys, and LDDMM revealed the groups remarkably differed in basal ganglia shapes. Volume compression was seen bilaterally in the caudate head and body and anterior putamen as well as in the left anterior globus pallidus and right ventral putamen. Volume expansion was most pronounced in the posterior putamen. No volume or shape differences were revealed in girls with ADHD. The shape compression pattern of basal ganglia in boys with ADHD suggests that ADHD-associated deviations from typical brain development involve multiple frontal-subcortical control loops, including circuits with premotor, oculomotor, and prefrontal cortices. Further investigations employing brain-behavior analyses will help to discern the task-dependent contributions of these circuits to impaired response control that is characteristic of ADHD.
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DOI：
10.1023/b:visi.0000043755.93987.aa
发表时间：
2005-02-01
影响因子：
19.5
作者：
Beg, MF;Miller, MI;Younes, L
通讯作者：
Younes, L
DOI：
10.1016/s0926-6410(03)00144-7
发表时间：
2003-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Mostofsky, SH;Schafer, JGB;Pekar, JJ
通讯作者：
Pekar, JJ
影响因子：
6.9
作者：
Overmeyer, S;Bullmore, ET;Taylor, E
通讯作者：
Taylor, E
影响因子：
120.7
作者：
Castellanos, FX;Lee, PP;Rapoport, JL
通讯作者：
Rapoport, JL
影响因子：
3.2
作者：
Gazzaley, A;Cooney, JW;D'Esposito, M
通讯作者：
D'Esposito, M