Enhanced top-down sensorimotor processing in somatic anxiety.
Enhanced top-down sensorimotor processing in somatic anxiety.
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DOI：
10.1038/s41398-022-02061-2
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发表时间：
2022-07-25
影响因子：
6.8
通讯作者：
Ray, Dipanjan
中科院分区：
文献类型：
--
作者：
Bouziane, Ismail;Das, Moumita;Friston, Karl J.;Caballero-Gaudes, Cesar;Ray, Dipanjan
焦虑的功能神经影像研究传统上集中于与焦虑的心理方面相关的大脑网络。相反，在这里，我们的目标是焦虑的躯体方面。人们越来越认识到自上而下的皮质处理在感知和行动中起着至关重要的作用，我们使用来自人类连接组项目和动态因果模型（DCM）的静息态功能 MRI 数据来表征外感受、内感受和运动皮质中分层组织区域之间的有效连接。在具有高（与恐惧相关的）躯体唤醒的人中，所有三个网络中自上而下的有效连接都得到了增强：这一观察结果很好地证实了焦虑的现象学。与焦虑相关的连通性变化足以可靠地预测新参与者是否患有轻度或严重的躯体焦虑。有趣的是，与感觉运动皮层自上而下连接的增加与恐惧影响分数无关，从而建立了焦虑的躯体维度和认知维度之间的（相对）分离。总体而言，感觉运动皮层自上而下有效连接的增强成为一种有前景且可量化的躯体焦虑特征候选标志。
Functional neuroimaging research on anxiety has traditionally focused on brain networks associated with the psychological aspects of anxiety. Here, instead, we target the somatic aspects of anxiety. Motivated by the growing appreciation that top-down cortical processing plays a crucial role in perception and action, we used resting-state functional MRI data from the Human Connectome Project and Dynamic Causal Modeling (DCM) to characterize effective connectivity among hierarchically organized regions in the exteroceptive, interoceptive, and motor cortices. In people with high (fear-related) somatic arousal, top-down effective connectivity was enhanced in all three networks: an observation that corroborates well with the phenomenology of anxiety. The anxiety-associated changes in connectivity were sufficiently reliable to predict whether a new participant has mild or severe somatic anxiety. Interestingly, the increase in top-down connections to sensorimotor cortex were not associated with fear affect scores, thus establishing the (relative) dissociation between somatic and cognitive dimensions of anxiety. Overall, enhanced top-down effective connectivity in sensorimotor cortices emerges as a promising and quantifiable candidate marker of trait somatic anxiety.
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影响因子：
10.6
作者：
Cornwell BR;Garrido MI;Overstreet C;Pine DS;Grillon C
通讯作者：
Grillon C
DOI：
10.1038/nrn3950
发表时间：
2015-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Barrett LF;Simmons WK
通讯作者：
Simmons WK
影响因子：
4.7
作者：
Dumontheil I
通讯作者：
Dumontheil I
影响因子：
5.7
作者：
Aitchison L;Lengyel M
通讯作者：
Lengyel M
影响因子：
3.1
作者：
Adams, Rick A.;Shipp, Stewart;Friston, Karl J.
通讯作者：
Friston, Karl J.