The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee.

The osteoarthritis initiative: report on the design rationale for the magnetic resonance imaging protocol for the knee.
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DOI:
10.1016/j.joca.2008.06.016
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发表时间:
2008-12
影响因子:
7
通讯作者:
Nevitt M
Nevitt M
中科院分区:
医学2区
文献类型:
--
作者:
Peterfy CG;Schneider E;Nevitt M

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报告在膝关节骨关节炎倡议(OAI)磁共振成像(MRI)研究方案中选择采集方案的过程和标准。从文献中确定的候选膝关节MR采集方案首先在3特斯拉(T)下进行优化。对10名受试者的12个膝关节进行一次扫描,其中16个被认为最有可能达到研究目标并具有最佳优化结果。在软骨-液体、软骨-脂肪、软骨-囊、软骨-半月板和软骨-软骨界面处评估所得图像和多平面重构对关节软骨的伪影和结构区分。根据成像方案的研究目标、图像评估结果以及在75分钟时间内对双膝进行成像(包括定位)的需要,对构成最终OAI MRI方案的五项采集进行了汇总。对于定量软骨形态测量,脂肪抑制,三维双回声稳态(DESS)采集似乎提供了最好的通用软骨鉴别。OAI膝关节MRI方案提供了与膝关节OA相关的多个关节结构和特征的成像数据,将支持广泛的现有和预期的测量方法,同时平衡对高图像质量和一致性的要求与大型多中心队列研究的实际考虑。最终的膝关节MRI方案的优势包括:由于薄切片的多平面重建,在三个平面上的软骨量化能力,高空间分辨率的3D DESS采集以及在T2松弛时间映射采集期间测量的多重非脂肪抑制图像对比度。
To report on the process and criteria for selecting acquisition protocols to include in the osteoarthritis initiative (OAI) magnetic resonance imaging (MRI) study protocol for the knee. Candidate knee MR acquisition protocols identified from the literature were first optimized at 3 Tesla (T). Twelve knees from 10 subjects were scanned one time with each of 16 acquisitions considered most likely to achieve the study goals and having the best optimization results. The resultant images and multi-planar reformats were evaluated for artifacts and structural discrimination of articular cartilage at the cartilage–fluid, cartilage–fat, cartilage–capsule, cartilage–meniscus and cartilage–cartilage interfaces. The five acquisitions comprising the final OAI MRI protocol were assembled based on the study goals for the imaging protocol, the image evaluation results and the need to image both knees within a 75 min time slot, including positioning. For quantitative cartilage morphometry, fat-suppressed, 3D dual-echo in steady state (DESS) acquisitions appear to provide the best universal cartilage discrimination. The OAI knee MRI protocol provides imaging data on multiple articular structures and features relevant to knee OA that will support a broad range of existing and anticipated measurement methods while balancing requirements for high image quality and consistency against the practical considerations of a large multi-center cohort study. Strengths of the final knee MRI protocol include cartilage quantification capabilities in three planes due to multi-planar reconstruction of a thin slice, high spatial resolution 3D DESS acquisition and the multiple, non-fat-suppressed image contrasts measured during the T2 relaxation time mapping acquisition.
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