Detection of HPV related oropharyngeal cancer in oral rinse specimens.
Detection of HPV related oropharyngeal cancer in oral rinse specimens.
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DOI：
10.18632/oncotarget.22682
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发表时间：
2017-12-12
期刊：
影响因子：
--
通讯作者：
Ganly I
中科院分区：
文献类型：
--
作者：
Rosenthal M;Huang B;Katabi N;Migliacci J;Bryant R;Kaplan S;Blackwell T;Patel S;Yang L;Pei Z;Tang YW;Ganly I
大多数被诊断为口咽鳞状细胞癌(OPSCC)的患者是由HPV感染引起的。目前，还没有可靠的检测方法来筛查OPSCC患者中的HPV。本研究的目的是评估口腔含漱液标本的Cobas®HPV检测作为HPV相关OPSCC的早期、非侵入性工具。口腔鳞状细胞癌(OPSCC)患者45例，口腔鳞状细胞癌(OCSCC)患者61例，良性或恶性甲状腺结节患者81例。Cobas®HPV检测用于检测这些样本中的14种高危HPV类型。HPV检测以p16肿瘤免疫组织化学为金标准。口咽癌p16阳性率为91.1%，口腔癌为3.3%。在81名对照组患者中，79名(97.5%)的口腔含漱液中没有HPV，HPV检测的特异度为98%。以p16免疫组织化学为参照，口腔口咽癌联合队列中HPV检测的敏感性、特异性、阳性预测值和阴性预测值分别为79.1%、90.5%、85.0%和86.4%。口腔含漱液的Cobas®HPV检测是一种对口咽癌具有高度特异性和潜在敏感性的测试，可能是一种潜在的有用的早期口咽癌筛查测试。我们描述了一种口腔漱口试验，用于检测HPV相关性口咽癌。
The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC. The Cobas® HPV Test was used to detect 14 high-risk HPV types in these samples. Performance of the HPV Test was correlated with p16 tumor immunohistochemistry as gold standard. 91.1% of the oropharynx cancer patients had p16 positive tumors compared to 3.3% of oral cavity cancer. Of the 81 control patients, 79 (97.5%) had no HPV in their oral rinse giving a specificity of the HPV test of 98%. For the combined oral cavity oropharynx cancer cohort, the sensitivity, specificity, positive predictive value and negative predictive value of the HPV Test were 79.1%, 90.5%, 85.0% and 86.4% respectively when p16 immunohistochemistry was used as the reference. The Cobas® HPV Test on oral rinse is a highly specific and potentially sensitive test for oropharyngeal cancer and may be a potentially useful screening test for early oropharyngeal cancer. We describe an oral rinse test for the detection of HPV related oropharyngeal cancer.
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影响因子：
28.4
作者：
Rettig EM;Wentz A;Posner MR;Gross ND;Haddad RI;Gillison ML;Fakhry C;Quon H;Sikora AG;Stott WJ;Lorch JH;Gourin CG;Guo Y;Xiao W;Miles BA;Richmon JD;Andersen PE;Misiukiewicz KJ;Chung CH;Gerber JE;Rajan SD;D'Souza G
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通讯作者：
Gillison, Maura L.
影响因子：
3.8
作者：
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通讯作者：
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影响因子：
45.3
作者：
Chaturvedi, Anil K.;Engels, Eric A.;Gillison, Maura L.
通讯作者：
Gillison, Maura L.