Effects of 2-MCPD on oxidative stress in different organs of male mice.
Effects of 2-MCPD on oxidative stress in different organs of male mice.
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2-MCPD对雄性小鼠不同器官氧化应激的影响。
DOI：
10.1016/j.fct.2020.111459
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Schultrich K
中科院分区：
文献类型：
--
作者：
Schultrich K
2-一氯丙烷-1，3-二醇（2-MCPD）及其异构体3-一氯丙烷-1，2-二醇（3-MCPD）是常见的食品污染物。3-MCPD已被归类为非遗传毒性致癌物，而2-MCPD的毒理学数据非常有限。动物研究表明，心脏和骨骼肌是2-MCPD的靶器官。氧化应激可能在这一过程中发挥作用，3-MCPD在体内诱导氧化应激的潜力已经得到证实。为了研究2-MCPD在体内诱导氧化应激的潜力，在雄性HOTT报告小鼠中进行了28天经口喂养研究。该小鼠模型允许根据Hmox 1启动子激活来监测各种靶器官中物质诱导的氧化应激。每日重复给药高达100 mg 2-MCPD/kg体重未导致实质性毒性。此外，最高剂量的2-MCPD仅对肾脏和睾丸的氧化应激产生轻微影响，而脑、心脏和骨骼肌未受影响。此外，2-MCPD仅引起Nrf 2依赖性基因表达的轻微变化，并且仅轻微影响氧化还原传感器蛋白DJ-1的氧化还原状态。因此，数据表明，与其异构体3-MCPD相比，2-MCPD不会显著诱导雄性小鼠的氧化应激。
2-Monochloropropane-1,3-diol (2-MCPD) and its isomer 3-monochloropropane-1,2-diol (3-MCPD) are widespread food contaminants. 3-MCPD has been classified as a non-genotoxic carcinogen, whereas very limited toxicological data are available for 2-MCPD. Animal studies indicate that heart and skeletal muscle are target organs of 2-MCPD. Oxidative stress may play a role in this process, and the potential of 3-MCPD to induce oxidative stressin vivohas already been demonstrated. To investigate the potential of 2-MCPD to induce oxidative stressin vivo, a 28-day oral feeding study in male HOTT reporter mice was conducted. This mouse model allows monitoring substance-induced oxidative stress in various target organs on the basis ofHmox1promoter activation. Repeated daily doses of up to 100 mg 2-MCPD/kg body weight did not result in substantial toxicity. Furthermore, the highest dose of 2-MCPD had only minor effects on oxidative stress in kidney and testes, whereas brain, heart and skeletal muscle were not affected. Additionally, 2-MCPD caused only mild changes in the expression of Nrf2-dependent genes and only slightly affected the redox status of the redox-sensor protein DJ-1. Thus, the data indicate that 2-MCPD, in contrast to its isomer 3-MCPD, does not lead to a considerable induction of oxidative stress in male mice.
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3-MCPD 诱导的雄性小鼠器官毒性与氧化应激反应之间的相关性。
DOI：
10.1016/j.fct.2019.110957
发表时间：
2020
期刊：
an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
Schultrich K
通讯作者：
Schultrich K
影响因子：
4.3
作者：
Buhrke, Thorsten;Schultrich, Katharina;Lampen, Alfonso
通讯作者：
Lampen, Alfonso
在一项为期 28 天的研究中，对 2-一氯丙二醇 (2-MCPD) 和 2-MCPD 二棕榈酸酯对大鼠肾脏和肝脏的毒性进行了蛋白质组学分析。
DOI：
10.1016/j.fct.2018.08.013
发表时间：
2018
期刊：
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
F. Frenzel;A. Oberemm;A. Braeuning;A. Lampen
通讯作者：
A. Lampen
影响因子：
4.3
作者：
Frenzel, Falko;Oberemm, Axel;Braeuning, Albert
通讯作者：
Braeuning, Albert