Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus
Altered Gray Matter Volume in Patients With Type 1 Diabetes Mellitus
复制标题
1 型糖尿病患者灰质体积的改变
DOI：
10.3389/fendo.2020.00045
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发表时间：
2020-02
影响因子：
5.2
通讯作者：
Jing Wang
中科院分区：
文献类型：
--
作者：
Jia Liu;Wenliang Fan;Yuxi Jia;Xiaoyun Su;Wenjun Wu;Xi Long;Xin Sun;Jie Liu;Wengang Sun;Tanjing Zhang;Qiyong Gong;Haojun Shi;Qing Zhu;Jing Wang
背景和目的：许多影像学研究报道了1型糖尿病（T1DM）患者使用基于体素的形态学（VBM）的结构改变。然而，报告的结果并不一致，而且没有进行定量审查。因此，进行了定量荟萃分析，包括T1DM患者的VBM研究。材料和方法：应用基于种子的d图软件，对T1DM患者的灰质体积改变进行估计。同时，采用Meta回归分析方法，对人口统计学特征和临床特征的影响进行分析。结果：最终纳入6篇文献，共6个数据集，包括414例T1DM患者和216例健康对照。汇总荟萃分析发现，T1 DM患者显示左侧背外侧上级回和额中回的灰质体积显著增加，右侧舌回、小脑、楔前叶、左侧颞下回和颞中回的灰质体积减少。Meta回归分析显示，T1DM患者的平均年龄、女性患者比例、病程和HbAlc%与灰质改变不呈线性相关。结论：本荟萃分析表明，T1DM患者的灰质体积减少主要位于皮层和小脑。
Background and Purpose: Many imaging studies have reported structure alterations in patients with type 1 diabetes mellitus (T1DM) by using voxel-based morphometry (VBM). Nevertheless, the results reported were inconsistent and had not been reviewed quantitatively. Accordingly, the quantitative meta-analysis which including VBM studies of patients with T1DM was conducted. Materials and Methods: The gray matter volume alterations in patients with T1DM was estimated by using the software seed-based d mapping. Meantime, the meta-regression was applied to detect the effects of some demographics and clinical characteristics. Results: Six studies were finally included, which with 6 datasets comprising 414 T1DM patients and 216 healthy controls. The pooled meta-analyses detected that patients with T1DM showed robustly increased gray matter volume in the left dorsolateral superior frontal gyrus and middle frontal gyrus and a decreased gray matter volume in the right lingual gyrus, cerebellum, precuneus, the left inferior temporal gyrus, and middle temporal gyrus. The meta-regression showed that the mean age, the female patient's ratio, duration of illness and HbAlc% for T1DM patients were not linearly related with gray matter alterations. Conclusion: This meta-analysis demonstrates that gray matter volume decreases in T1DM patients were mainly locates in the cortical regions and cerebellum.
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影响因子：
7.7
作者：
Franc DT;Kodl CT;Mueller BA;Muetzel RL;Lim KO;Seaquist ER
通讯作者：
Seaquist ER
影响因子：
1.7
作者：
Liu, Kun;Huang, Xiaoyan;Lin, Xiangtao
通讯作者：
Lin, Xiangtao
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
创伤后应激障碍 (PTSD) 中创伤特定的灰质改变。
影响因子：
4.6
作者：
Meng L;Jiang J;Jin C;Liu J;Zhao Y;Wang W;Li K;Gong Q
通讯作者：
Gong Q
影响因子：
16.2
作者：
van Elderen SG;Brandts A;van der Grond J;Westenberg JJ;Kroft LJ;van Buchem MA;Smit JW;de Roos A
通讯作者：
de Roos A