Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study.
Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study.
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DOI：
10.1289/ehp.1306925
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发表时间：
2014-05
影响因子：
10.4
通讯作者：
Wang SL
中科院分区：
文献类型：
--
作者：
Wang Y;Rogan WJ;Chen PC;Lien GW;Chen HY;Tseng YC;Longnecker MP;Wang SL
背景：全氟烷基物质（PFAS）是在工业中广泛使用的合成化合物，并且通常可以在人体中检测到。在怀孕的大鼠及其幼崽中，PFAS 会干扰甲状腺激素的稳态。在人类中，母亲的甲状腺激素在整个怀孕期间为胎儿提供营养，甲状腺激素在胎儿的生长和神经发育中起着至关重要的作用。目的：我们调查了孕妇 PFAS 暴露与孕妇和新生儿甲状腺激素状态之间的关联。方法：在台湾的一项环境暴露与健康研究中，我们测量了 285 名妊娠晚期孕妇的 9 种 PFAS 和 4 种甲状腺激素的血清浓度，并测量了 116 名新生儿的脐带血清甲状腺激素。在多元线性回归模型中检查了母体 PFAS 与母体甲状腺激素和脐带甲状腺激素之间的关联。结果：全氟己磺酸浓度与母体促甲状腺激素（TSH）水平呈正相关。全氟壬酸 (PFNA)、全氟十一烷酸 (PFUnDA) 和全氟十二烷酸 (PFDoDA) 水平较高的孕妇，其游离甲状腺素 (T4) 和总 T4 水平较低。例如，我们估计，母体 PFNA 每增加 1 纳克/毫升，母体游离 T4 水平就会降低 0.019 ng/dL（95% CI：–0.028，–0.009）。最后，母体 PFNA、PFUnDA 和 PFDoDA 水平与较低的脐带总三碘甲状腺原氨酸 (T3) 和总 T4 水平相关，母体全氟癸酸 (PFDeA) 与较低的脐带总 T3 相关。结论：我们的结果表明，怀孕期间接触某些 PFAS 可能会干扰孕妇和胎儿的甲状腺激素稳态。引用: Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL。 2014. 怀孕期间母体血清全氟烷基物质与母体和脐带甲状腺激素之间的关联：台湾母婴队列研究。环境健康视角 122：529–534； http://dx.doi.org/10.1289/ehp.1306925
Background: Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and are often detectable in humans. In pregnant rats and their pups, PFASs can interfere with thyroid hormone homeostasis. In humans, maternal thyroid hormones supply the fetus throughout pregnancy, and thyroid hormones play a critical role in fetal growth and neurodevelopment. Objectives: We investigated the association between maternal PFAS exposure and thyroid hormone status in pregnant women and neonates. Methods: In a study of environmental exposure and health in Taiwan, we measured serum concentrations of nine PFASs and four thyroid hormones for 285 pregnant women in their third trimester, and also measured cord serum thyroid hormones for 116 neonates. Associations between maternal PFASs and maternal and cord thyroid hormones were examined in multiple linear regression models. Results: Perfluorohexanesulfonic acid concentrations were positively associated with maternal thyroid-stimulating hormone (TSH) levels. Pregnant women with higher levels of perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) had lower free thyroxine (T4) and total T4 levels. For example, we estimated that maternal free T4 levels decreased 0.019 ng/dL (95% CI: –0.028, –0.009) with each nanogram per milliliter increase in maternal PFNA. Finally, maternal PFNA, PFUnDA, and PFDoDA levels were associated with lower cord total triiodothyronine (T3) and total T4 levels, and maternal perfluorodecanoic acid (PFDeA) was associated with lower cord total T3. Conclusions: Our results suggest that exposure to some PFASs during pregnancy may interfere with thyroid hormone homeostasis in pregnant women and fetuses. Citation: Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL. 2014. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan Maternal and Infant Cohort Study. Environ Health Perspect 122:529–534; http://dx.doi.org/10.1289/ehp.1306925
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DOI：
10.1097/00001648-199001000-00010
发表时间：
1990-01-01
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Rothman, K J
通讯作者：
Rothman, K J
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
4.1
作者：
GoeckeFlora, CM;Reo, NV
通讯作者：
Reo, NV
影响因子：
5.8
作者：
Boas, Malene;Forman, Juhe Lyng;Main, Katharina M.
通讯作者：
Main, Katharina M.
影响因子：
1.5
作者：
Fisher, DA
通讯作者：
Fisher, DA