The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology.
The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology.
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明尼苏达双胞胎家庭研究的富集研究：增加了外部化精神病理风险高风险的双胞胎家族的产量。
DOI：
10.1375/twin.12.5.489
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发表时间：
2009-10
期刊：
影响因子：
--
通讯作者：
Iacono WG
中科院分区：
文献类型：
--
作者：
Keyes MA;Malone SM;Elkins IJ;Legrand LN;McGue M;Iacono WG
富集研究（ES）旨在扩展明尼苏达州双胞胎家庭研究（MTFS），通过对11岁的双胞胎进行过采样，这些双胞胎因患有儿童期破坏性障碍而具有特别高的物质使用障碍风险。样本是从明尼苏达州的出生记录中确定的。为了识别高危双胞胎，我们对父母报告的注意力缺陷/多动障碍（ADHD）和品行障碍（CD）症状以及学业脱离的迹象进行了电话筛选访谈。超过预定阈值的双胞胎被邀请参加。为了便于与先前确定的MTFS参与者进行比较，还招募了11岁双胞胎的随机样本。作为ES研究的一部分，499对双胞胎和他们的父母访问了明尼苏达大学，每个参与者都完成了临床访谈，心理生理评估和环境风险的全面评估。我们在招募高危双胞胎方面非常成功; 52%的筛查男性双胞胎和41%的筛查女性双胞胎符合ADHD、CD或对立违抗性障碍（ODD）的诊断标准。在配对水平上，63%的筛选配对中至少有一个成员患有儿童期破坏性障碍。本文提供了一个研究设计的概述，并包括使用此双胞胎样本的最新研究结果的审查。
The Enrichment Study (ES) was designed to extend the Minnesota Twin Family Study (MTFS) by oversampling 11-year-old twins at especially high risk for substance use disorders by virtue of having a childhood disruptive disorder. The sample was ascertained from Minnesota birth records. To identify high-risk twins, we conducted telephone screening interviews for parent-reported symptoms of attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) as well as indications of academic disengagement. Twins who exceeded a predetermined threshold were invited to participate. To facilitate comparison with the previously ascertained MTFS participants, a random sample of 11-year-old twins was also recruited. As part of the ES study, 499 twin pairs, and their parents, visited the University of Minnesota where each participant completed a clinical interview, psychophysiological evaluation, and thorough assessment of environmental risk. We were highly successful in recruiting at-risk twins; 52% of the screened male twins and 41% of the screened females met criteria for a diagnosis of ADHD, CD, or oppositional defiant disorder (ODD). At the pair level, 63% of the screened pairs had at least one member with a childhood disruptive disorder. This article provides an overview of the study design and includes a review of recent findings using this sample of twins.
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影响因子：
10.6
作者：
Habeych, ME;Charles, PJ;Tarter, RE
通讯作者：
Tarter, RE
DOI：
10.1080/10401230600801077
发表时间：
2006-07-01
期刊：
Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists
影响因子：
--
作者：
Adler, Lenard A;Spencer, Thomas;Secnik, Kristina
通讯作者：
Secnik, Kristina
DOI：
10.1111/j.1469-7610.2005.01461.x
发表时间：
2006-02-01
影响因子：
7.6
作者：
Cukrowicz, KC;Taylor, J;Iacono, WG
通讯作者：
Iacono, WG
影响因子：
--
作者：
Elkins, Irene J.;McGue, Matt;Iacono, William G.
通讯作者：
Iacono, William G.
影响因子：
3.7
作者：
Carlson, SR;Iacono, WG;McGue, M
通讯作者：
McGue, M