CRH-stimulated cortisol release and food intake in healthy, non-obese adults.
CRH-stimulated cortisol release and food intake in healthy, non-obese adults.
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CRH 刺激健康、非肥胖成年人的皮质醇释放和食物摄入。
DOI：
10.1016/j.psyneuen.2009.09.017
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发表时间：
2010-05
影响因子：
3.7
通讯作者：
Abelson, James L.
中科院分区：
文献类型：
--
作者：
George, Sophie A.;Khan, Samir;Briggs, Hedieh;Abelson, James L.
有相当多的轶事和一些科学证据表明，压力会引发饮食行为，但潜在的生理机制仍然不确定。下丘脑-垂体-肾上腺（HPA）轴是生理应激反应的关键介质，可能在应激和食物摄入之间的联系中发挥作用。皮质醇对实验室压力源的反应可以预测消费，但目前还不清楚这种反应是否标志着与压力有关的饮食的脆弱性，或者皮质醇是否直接刺激人类的饮食。我们向健康成人注入促肾上腺皮质激素释放激素（CRH），其剂量主观上无法检测到，但能激发强大的内源性皮质醇反应，并测量随后的零食摄入量，从而分析HPA反应性对食物摄入量的影响，而无需压力范式的复杂心理影响。CRH升高皮质醇水平相对于安慰剂，但不影响主观焦虑困扰。受试者吃更多的CRH后比安慰剂和峰值皮质醇反应CRH是强烈相关的热量摄入和总消费。这些数据表明，HPA轴对药理学刺激的反应性预测随后的食物摄入量，并表明皮质醇本身可能直接刺激人类的食物消耗。了解与压力有关的饮食的生理机制可能有助于解决肥胖造成的公共卫生危机。
There is considerable anecdotal and some scientific evidence that stress triggers eating behavior, but underlying physiological mechanisms remain uncertain. The hypothalamic-pituitary-adrenal (HPA) axis is a key mediator of physiological stress responses and may play a role in the link between stress and food intake. Cortisol responses to laboratory stressors predict consumption but it is unclear whether such responses mark a vulnerability to stress-related eating or whether cortisol directly stimulates eating in humans. We infused healthy adults with corticotropin-releasing hormone (CRH) at a dose that is subjectively undetectable but elicits a robust endogenous cortisol response, and measured subsequent intake of snack foods, allowing analysis of HPA reactivity effects on food intake without the complex psychological effects of a stress paradigm. CRH elevated cortisol levels relative to placebo but did not impact subjective anxious distress. Subjects ate more following CRH than following placebo and peak cortisol response to CRH was strongly related to both caloric intake and total consumption. These data show that HPA axis reactivity to pharmacological stimulation predicts subsequent food intake and suggest that cortisol itself may directly stimulate food consumption in humans. Understanding the physiological mechanisms that underlie stress-related eating may prove useful in efforts to attack the public health crises created by obesity.
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