Dopamine Multilocus Genetic Profile, Spontaneous Activity of Left Superior Temporal Gyrus, and Early Therapeutic Effect in Major Depressive Disorder.
Dopamine Multilocus Genetic Profile, Spontaneous Activity of Left Superior Temporal Gyrus, and Early Therapeutic Effect in Major Depressive Disorder.
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DOI：
10.3389/fpsyt.2020.591407
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发表时间：
2020
影响因子：
4.7
通讯作者：
Yuan Y
中科院分区：
文献类型：
--
作者：
Liu X;Hou Z;Yin Y;Xie C;Zhang H;Zhang H;Zhang Z;Yuan Y
目的：研究多巴胺(DA)通路基因与疾病的交互作用对自发性脑活动的影响，进一步探讨自发性脑活动与早期抗抑郁药物治疗的关系。方法：选择MDD患者104例和健康对照组(HCS)。采用汉密尔顿抑郁量表(HAMD-24)评定抑郁严重程度。两组均行静息功能磁共振成像(rs-fMRI)扫描。根据rS-fMRI数据计算低频波动幅度(ALF)以反映脑自发活动。治疗2周后，再次评定抑郁严重程度，用HAMD-24减分率评定抗抑郁药物的疗效。用多位点遗传图谱评分(MGPS)评价DA途径基因的多点累积效应。用多元线性回归分析检测MDD和DA通路基因对各脑区ALF的交互作用。最后，进行偏相关分析(以年龄、性别、教育程度和病程为协变量)以确定局部ALF与疗效的关系。结果：MDD和DA-MGPS对左侧梭形回(FG_L)、右侧距骨沟(CS_R)、左侧颞上回(STG_L)、双侧小脑后叶(CPL)、双侧额下回(IFG)和双侧额上回(SFG)有交互作用。偏相关分析显示，STG_L的ALFF与2周HAMD-24减分率呈显著负相关(r=−0.211，P=0.035)。结论：STG_L自发活动可能是MDD抗抑郁相关早期疗效的潜在生物标志物，其机制可能与DA通路基因有关。
Objectives: This study aimed to examine the interactive effects of dopamine (DA) pathway gene and disease on spontaneous brain activity and further to explore the relationship between spontaneous brain activity and the early antidepressant therapeutic effect in patients with major depressive disorder (MDD). Methods: A total of 104 patients with MDD and 64 healthy controls (HCs) were recruited. The Hamilton Depression Scale-24 (HAMD-24) was used to measure the depression severity. Both groups were given resting-state functional magnetic resonance imaging (rs-fMRI) scan. The amplitude of low-frequency fluctuation (ALFF) was calculated to reflect the spontaneous brain activity based on the rs-fMRI data. After treatment for 2 weeks, depression severity was evaluated again, and HAMD-24 reductive rate was used to measure the therapeutic effect of antidepressants. Multilocus genetic profile scores (MGPS) were used to assess the multi-site cumulative effect of DA pathway gene. The interactive effects of MDD and DA pathway gene on the ALFF of regional brain areas were measured by the multivariate linear regression analysis. Finally, partial correlation analysis (age, sex, education, and illness durations as covariates) was performed to identify the relationship between regional ALFF and therapeutic effect. Results: MDD and DA-MGPS had interactive effects on the left fusiform gyrus (FG_L), right calcarine sulcus (CS_R), left superior temporal gyrus (STG_L), bilateral cerebellum posterior lobe (CPL), bilateral inferior frontal gyrus (IFG), and bilateral superior frontal gyrus (SFG). Partial correlation analysis revealed that the ALFF of STG_L had a significant negative correlation with 2-week HAMD-24 reductive rate (r = −0.211, P = 0.035). Conclusions: The spontaneous activity of STG_L may be a potential biomarker of antidepressant-related early therapeutic effect underlying the influence of DA pathway genes in MDD.
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DOI：
10.1523/jneurosci.1506-12.2012
发表时间：
2012-07-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Stice E;Yokum S;Burger K;Epstein L;Smolen A
通讯作者：
Smolen A
影响因子：
1.7
作者：
Mohammadi, Hiwa;Joghataei, Mohammad Taghi;Farhangdoost, Hashem
通讯作者：
Farhangdoost, Hashem
DOI：
10.1007/s00406-019-01040-x
发表时间：
2020-03-01
影响因子：
4.7
作者：
Avinun, Reut;Nevo, Adam;Hariri, Ahmad R.
通讯作者：
Hariri, Ahmad R.
DOI：
10.1016/j.pnpbp.2018.05.012
发表时间：
2018-08-30
影响因子：
5.6
作者：
Pereira LP;Köhler CA;Stubbs B;Miskowiak KW;Morris G;de Freitas BP;Thompson T;Fernandes BS;Brunoni AR;Maes M;Pizzagalli DA;Carvalho AF
通讯作者：
Carvalho AF
局部功能连接密度与重度抑郁症电惊厥治疗的反应密切相关。
影响因子：
6.6
作者：
Wang, Jiaojian;Wei, Qiang;Wang, Kai
通讯作者：
Wang, Kai