Carotenoids, retinol, and vitamin E and risk of proliferative benign breast disease and breast cancer.

Carotenoids, retinol, and vitamin E and risk of proliferative benign breast disease and breast cancer.
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类胡萝卜素、视黄醇和维生素 E 与增生性良性乳腺疾病和乳腺癌的风险。

DOI:
10.1007/bf00052746
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发表时间:
1992
期刊:
Cancer causes & control : CCC
影响因子:
--
通讯作者:
Willett,WC
Willett,WC
中科院分区:
--
文献类型:
--
作者:
London,SJ;Stein,EA;Henderson,IC;Stampfer,MJ;Wood,WC;Remine,S;Dmochowski,JR;Robert,NJ;Willett,WC

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我们对美国马萨诸塞州波士顿地区绝经后妇女进行了一项病例对照研究,调查了血清视黄醇、β-胡萝卜素、α-胡萝卜素、番茄红素、α-生育酚和γ-生育酚水平以及视黄醇、胡萝卜素和维生素E摄入量与乳腺癌和增生性良性乳腺疾病(BBD)风险之间的关系。377名新诊断的I期或II期乳腺癌妇女和173名增殖性BBD妇女的血清营养数据可用。对照组为403名在同一机构接受评估但不需要乳腺活检或活检显示非增殖性BBD的妇女。我们观察到这些微量营养素的血清水平与增殖性BBD或乳腺癌的风险之间没有显着关联。仅从食物来源摄入维生素E最多的五分之一妇女患乳腺癌的风险降低(最高五分位数的比值比[OR]= 0.4,95%置信区间[CI]=0.2-0.9;P,五分位数之间的趋势= 0.02),但包括补充剂在内的维生素E总摄入量的比值比[OR]较低(OR=0.7,CI=0.4-1.3;P,趋势= 0.07)。
We investigated the relationship between serum levels of retinol, β-carotene, α-carotene, lycopene, α-tocopherol, and γ-tocopherol as well as intakes of retinol, carotene, and vitamin E and the risks of breast cancer and proliferative benign breast disease (BBD) in a case-control study of postmenopausal women in the Boston, MA (United States) area. Serum nutrient data were available for 377 women with newly diagnosed stage I or II breast cancer and 173 women with proliferative BBD. Controls were 403 women who were evaluated at the same institutions but did not require a breast biopsy or whose biopsy revealed nonproliferative BBD. We observed no significant associations between serum levels of these micronutrients and risk of proliferative BBD or breast cancer. The risk of breast cancer was decreased among women in the highest quintile of intake of vitamin E from food sources only (odds ratio [OR] for the highest quintile = 0.4,95 percent confidence interval [CI]=0.2–0.9;P, trend across quintiles = 0.02) but less so for total vitamin E intake including supplements (OR=0.7, CI=0.4–1.3;P, trend = 0.07).
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