Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes
Fabrication and drug release properties of curcumin-loaded silk fibroin nanofibrous membranes
复制标题
姜黄素丝素蛋白纳米纤维膜的制备及药物释放性能
DOI：
10.1177/0263617418820416
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发表时间：
2018-12
影响因子：
2.9
通讯作者：
Gang Li
中科院分区：
文献类型：
--
作者：
Xusheng Xie;Jia Yu;Zeyu Zhao;Zhaozhu Zheng;Maobin Xie;Xiaoqin Wang;Zhifen Han;Gang Li
采用静电纺丝技术制备了一种以丝素为基础的纳米纤维膜，该膜负载抗肿瘤药物姜黄素和5-氟尿嘧啶。结果表明，静电纺丝用丝素溶液中姜黄素/5-氟尿嘧啶的浓度分别为0.15/0.25、0.3/0.5和0.45/0.75 wt%。测定了纳米纤维膜的形态、亲水性、孔径、二级结构和抗肿瘤药物释放量。纳米纤维膜的直径约为100-200 nm。结果表明，静电纺丝过程对抗肿瘤药物的二级结构和药物含量没有影响，包封在丝素纳米纤维膜内的双重药物释放过程稳定一致。综上所述，基于丝素蛋白的载药膜可作为具有抗肿瘤功能的生物材料。
This paper describes a silk fibroin-based nanofibrous membranes loaded with antitumor drugs curcumin and 5-fluorouracil using electrospinning technique. The concentration of curcumin/5-fluorouracil in the silk fibroin solution for electrospinning was optimized to be 0.15/0.25, 0.3/0.5, and 0.45/0.75 wt%. The morphology, hydrophilic property, pore size, secondary structure, and antitumor drugs release of nanofibrous membranes were measured. The diameter of nanofibrous membranes ranged about 100–200 nm. The results indicated that electrospinning process did not influence the secondary structure and the drug content of antitumor drugs, and dual drugs encapsulated in the silk fibroin nanofibrous membranes were released in a steady and consistent process. In conclusion, the silk fibroin-based drug-loaded membranes can be useful as biomaterials with antitumor function.
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影响因子：
3
作者：
M. Tsukada
通讯作者：
M. Tsukada
影响因子：
2.9
作者：
Yuanxiang Jin;Yu-yin Chen;Meng-kui Xu;Yonghuang Jiang
通讯作者：
Yuanxiang Jin;Yu-yin Chen;Meng-kui Xu;Yonghuang Jiang
影响因子：
3.4
作者：
Wang, Hai-Yan;Zhang, Yu-Qing
通讯作者：
Zhang, Yu-Qing
影响因子：
4.5
作者：
Sharma, Chhavi;Kaur, Jatinder;Ralhan, Ranju
通讯作者：
Ralhan, Ranju
影响因子：
3.2
作者：
Xuchen Tao;C. Hu;Zhenzhen Xu;Meifang Zhu;Maobin Xie;Yi Li;Gang Li
通讯作者：
Xuchen Tao;C. Hu;Zhenzhen Xu;Meifang Zhu;Maobin Xie;Yi Li;Gang Li