Structural Insights into Ca(2+) Permeation through Orai Channels.
Structural Insights into Ca(2+) Permeation through Orai Channels.
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对 Ca2 通过 Orai 通道渗透的结构见解
作者：
Li Y;Yang X;Shen Y
奥赖通道属于钙释放激活钙（CRAC）通道家族。奥赖通道负责由内质网（ER）的Ca 2+耗尽触发的细胞外Ca 2+的内流;该功能对于许多类型的非兴奋细胞是必需的。广泛的结构和功能研究已经推进了奥赖通道被激活的分子机制的知识。然而，门控机制，使钙离子渗透通过奥赖通道是不太好的解释。本文对奥赖通道的结构研究进行了综述。我们详细介绍了奥赖通道的结构特征，描述了其封闭和开放状态的结构比较，并最终提出了一个“推拉”的钙渗透模型。
Orai channels belong to the calcium release-activated calcium (CRAC) channel family. Orai channels are responsible for the influx of extracellular Ca2+ that is triggered by Ca2+ depletion from the endoplasmic reticulum (ER); this function is essential for many types of non-excitable cells. Extensive structural and functional studies have advanced the knowledge of the molecular mechanism by which Orai channels are activated. However, the gating mechanism that allows Ca2+ permeation through Orai channels is less well explained. Here, we reviewed and summarized the existing structural studies of Orai channels. We detailed the structural features of Orai channels, described structural comparisons of their closed and open states, and finally proposed a “push–pull” model of Ca2+ permeation.
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影响因子：
64.5
作者：
Park CY;Hoover PJ;Mullins FM;Bachhawat P;Covington ED;Raunser S;Walz T;Garcia KC;Dolmetsch RE;Lewis RS
通讯作者：
Lewis RS
影响因子：
5.2
作者：
Feske S
通讯作者：
Feske S
DOI：
10.1126/science.1228757
发表时间：
2012-12-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hou X;Pedi L;Diver MM;Long SB
通讯作者：
Long SB
影响因子：
64.8
作者：
McNally, Beth A.;Somasundaram, Agila;Yamashita, Megumi;Prakriya, Murali
通讯作者：
Prakriya, Murali
影响因子：
64.8
作者：
HOTH, M;PENNER, R
通讯作者：
PENNER, R