Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.
Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals.
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DOI：
10.1101/gad.307884.117
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发表时间：
2018-01-15
影响因子：
10.5
通讯作者：
Hamada FN
中科院分区：
文献类型：
--
作者：
Goda T;Doi M;Umezaki Y;Murai I;Shimatani H;Chu ML;Nguyen VH;Okamura H;Hamada FN
Goda等人提供了体温节律（BTR）与运动活动节律不同的分子证据，并表明利尿激素31受体/降钙素受体是从外温动物到内温动物的生物体活动期BTR的古老特异性介质。每日体温节律（BTR）对于维持体内平衡至关重要。BTR与运动活动节律分开调节，但其分子基础在很大程度上未知。虽然哺乳动物内部调节BTR，但包括果蝇在内的外温动物表现出温度偏好节律（TPR）行为来调节BTR。在这里，我们证明了利尿激素31受体（DH 31 R）介导的TPR在果蝇的活跃期。DH 31 R在时钟细胞中表达，其配体DH 31作用于时钟细胞以在活动期调节TPR。令人惊讶的是，DH 31 R的小鼠同源物降钙素受体（Calcr）在小鼠的视交叉上核（SCN）中表达，并在活动期期间介导体温波动。重要的是，DH 31 R和Calcr不需要协调运动活动节律。我们的研究结果代表的第一个分子证据表明，BTR调节明显从自发活动的节奏，并表明，DH 31 R/钙是一个古老的特定介质的BTR在活跃阶段的生物体，从外温动物到内温动物。
Goda et al. provide molecular evidence that body temperature rhythm (BTR) is regulated distinctly from locomotor activity rhythms and show that diuretic hormone 31 receptor/calcitonin receptor is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms. Daily body temperature rhythm (BTR) is essential for maintaining homeostasis. BTR is regulated separately from locomotor activity rhythms, but its molecular basis is largely unknown. While mammals internally regulate BTR, ectotherms, including Drosophila, exhibit temperature preference rhythm (TPR) behavior to regulate BTR. Here, we demonstrate that the diuretic hormone 31 receptor (DH31R) mediates TPR during the active phase in Drosophila. DH31R is expressed in clock cells, and its ligand, DH31, acts on clock cells to regulate TPR during the active phase. Surprisingly, the mouse homolog of DH31R, calcitonin receptor (Calcr), is expressed in the suprachiasmatic nucleus (SCN) and mediates body temperature fluctuations during the active phase in mice. Importantly, DH31R and Calcr are not required for coordinating locomotor activity rhythms. Our results represent the first molecular evidence that BTR is regulated distinctly from locomotor activity rhythms and show that DH31R/Calcr is an ancient specific mediator of BTR during the active phase in organisms ranging from ectotherms to endotherms.
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影响因子：
64.8
作者：
Gerhart-Hines Z;Feng D;Emmett MJ;Everett LJ;Loro E;Briggs ER;Bugge A;Hou C;Ferrara C;Seale P;Pryma DA;Khurana TS;Lazar MA
通讯作者：
Lazar MA
影响因子：
5.3
作者：
Harrisingh, Marie C.;Wu, Ying;Nitabach, Michael N.
通讯作者：
Nitabach, Michael N.
影响因子：
3
作者：
Bedont JL;Blackshaw S
通讯作者：
Blackshaw S
DOI：
10.1002/cne.22311
发表时间：
2010-06-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Im SH;Taghert PH
通讯作者：
Taghert PH
影响因子：
18.2
作者：
Allada R;Chung BY
通讯作者：
Chung BY