Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region.
Serum 25-hydroxyvitamin D levels in patients with cutaneous lupus erythematosus in a Mediterranean region.
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DOI：
10.1177/0961203309360807
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发表时间：
2010-06
期刊：
影响因子：
2.6
通讯作者：
Grant W
中科院分区：
文献类型：
--
作者：
Cutillas-Marco E;Morales-Suárez-Varela M;Marquina-Vila A;Grant W
在自身免疫性疾病患者中发现维生素D水平较低，包括I型糖尿病、类风湿性关节炎、多发性硬化症和系统性红斑狼疮。维生素D的主要来源是暴露在阳光下，但同样的太阳辐射也会加剧红斑狼疮。我们调查了皮肤红斑狼疮（CLE）患者维生素D不足的患病率。我们设计了一项横断面研究，包括55名CLE患者，通过化学发光免疫分析法测量他们的血清25(OH)D (25(OH)D)，并将其与由37名性别和年龄匹配的健康受试者组成的对照组进行比较，这些受试者来自患者的亲属和医护人员。确定与临床和人口统计学变量的相关性。大约95%的CLE患者血清25(OH)D含量低于30 ng/ml，这被认为是维生素D充足性的下限。平均血清维生素D值显著低于对照组（p = 0.038），并与甲状旁腺激素水平升高相关（p = 0.050）。CLE病史是维生素D不足的有力预测因子（优势比4.2；95%可信区间1.0-17.4）。结果表明，CLE在维生素代谢中的作用，并为未来研究维生素D在预防和治疗CLE中的潜在作用提供指导。
Low vitamin D levels have been found in patients with autoimmune diseases, including type I diabetes, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus. The main source of vitamin D is exposure to sunlight, but the same solar radiation is known to exacerbate lupus erythematosus. We investigated the prevalence of vitamin D insufficiency in patients with cutaneous lupus erythematosus (CLE). We designed a cross-sectional study including 55 patients with CLE to measure their serum 25-hydroxyvitamin D (25(OH)D) by chemiluminescence immunoassay and compare it with a control group consisting of 37 healthy sex and age-matched subjects recruited from the patients’ relatives as well as healthcare workers. Correlations with clinical and demographic variables were determined. Approximately 95% of patients with CLE had less than 30 ng/ml of serum 25(OH)D, which is accepted as the lower limit for vitamin D adequacy. Mean serum vitamin D values were significantly lower than controls (p = 0.038) and were associated with higher levels of parathyroid hormone (p = 0.050). A history of CLE was a strong predictor of insufficiency of vitamin D (odds ratio 4.2; 95% confidence interval 1.0–17.4). The results suggest a role of CLE in the metabolism of the vitamin and provide guidance for future studies looking at a potential role for vitamin D in the prevention and treatment of CLE.
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影响因子：
4
作者：
Borba, V. Z. C.;Vieira, J. G. H.;Lazaretti-Castro, M.
通讯作者：
Lazaretti-Castro, M.
影响因子：
27.4
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DOI：
10.1111/j.1600-0781.2008.00373.x
发表时间：
2008-10-01
影响因子：
2.6
作者：
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通讯作者：
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影响因子：
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作者：
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