Adherence to highly active antiretroviral therapy and associated factors among children at the University of Gondar Hospital and Gondar Poly Clinic, Northwest Ethiopia: a cross-sectional institutional based study.
Adherence to highly active antiretroviral therapy and associated factors among children at the University of Gondar Hospital and Gondar Poly Clinic, Northwest Ethiopia: a cross-sectional institutional based study.
复制标题
DOI：
10.1186/1471-2458-14-875
复制
发表时间：
2014-08-26
影响因子：
4.5
通讯作者：
Birhanu AM
中科院分区：
文献类型：
--
作者：
Dachew BA;Tesfahunegn TB;Birhanu AM
抗逆转录病毒治疗（ART）在抑制病毒复制和延缓获得性免疫缺陷综合征（AIDS）进展方面的疗效与最佳依从性有关。所有接受抗逆转录病毒治疗的艾滋病毒感染者都面临着依从性的挑战。由于与儿童相关的因素，如年龄、艾滋病毒血清状态的披露状况以及对药物的理解，儿童尤其令人担忧。本研究评估了埃塞俄比亚西北部贡达尔大学医院和贡达尔保利诊所儿童对高效抗逆转录病毒治疗的依从性及其相关因素。2012年1月至3月进行了基于机构的横断面研究设计。采用简单随机抽样技术选择研究参与者，共342名研究受试者入选研究。进行双变量和多变量logistic回归分析，以确定与坚持高效抗逆转录病毒治疗相关的因素。计算比值比和95%置信区间以确定显著性水平。儿童的总体抗逆转录病毒疗法坚持率为90.4%。儿童的年龄[AOR = 0.37（95%CI：0.31，0.46）]、向儿童披露儿童的HIV状态[AOR = 0.27（95%CI：0.24，0.32）]和照顾者对ART药物的了解[AOR = 4.7（95%CI：3.7，5.6）]与依从性独立相关。抗逆转录病毒疗法的坚持率很高。向儿童披露儿童的艾滋病毒血清状况、儿童的年龄和照顾者对抗逆转录病毒疗法的了解是与坚持治疗相关的因素。
The efficacy of antiretroviral therapy (ART) in suppressing viral replication and delaying the progress of the acquired immunodeficiency syndrome (AIDS) is related to optimal adherence. Adherence is a challenge in all HIV infected people on ART. It is especially a concern in children because of factors relating to children such as age, disclosure status of HIV sero status, and understanding of the medication. This study assessed the level of adherence to highly active antiretroviral therapy and its associated factors among children in Gondar University Hospital and Gondar Poly Clinic, Northwest Ethiopia. Institutionally based cross-sectional study design was conducted from January-to March 2012. Simple random sampling technique was used to select study participants and a total of 342 study subjects were included in the study. Bivariate and multivariate logistic regressions were performed to identify associated factors with adherence to highly active antiretroviral therapy. Odds ratios with 95% confidence interval were computed to determine the level of significance. The overall ART adherence among children was found to be 90.4%. Age of the child [AOR = 0.37 (95% CI: 0.31, 0.46)], disclosure of the child’s HIV status to the child [AOR = 0.27 (95% CI: 0.24, 0.32)], and knowledge of caregivers about ART medication [AOR = 4.7 (95% CI (3.7, 5.6)], were independently associated with adherence. Adherence rate to ART was found to be high. Disclosure of the child’s HIV sero status to the child, the age of the child and the knowledge of the caregivers towards ART were factors associated with adherence.
登录
查看更多内容
影响因子：
4.9
作者：
Fetzer, Bradley C.;Mupenda, Bavon;Behets, Frieda
通讯作者：
Behets, Frieda
影响因子：
3.8
作者：
Giacomet, V;Albano, F;Guarino, A
通讯作者：
Guarino, A
影响因子：
2.4
作者：
Biadgilign, Sibhatu;Deribew, Amare;Deribe, Kebede
通讯作者：
Deribe, Kebede
影响因子：
4.4
作者：
Polisset, Julie;Ametonou, Francine;Perez, Freddy
通讯作者：
Perez, Freddy
影响因子：
--
作者：
Nabukeera-Barungi, Nicolette;Kalyesubula, Israel;Musoke, Philippa
通讯作者：
Musoke, Philippa