The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice.
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DOI：
10.1016/j.cmet.2014.02.009
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发表时间：
2014-03-04
期刊：
影响因子：
29
通讯作者：
Simpson SJ
中科院分区：
文献类型：
--
作者：
Solon-Biet SM;McMahon AC;Ballard JW;Ruohonen K;Wu LE;Cogger VC;Warren A;Huang X;Pichaud N;Melvin RG;Gokarn R;Khalil M;Turner N;Cooney GJ;Sinclair DA;Raubenheimer D;Le Couteur DG;Simpson SJ
什么是常量营养均衡的饮食，以及它如何保持健康和长寿，这些基本问题仍然没有答案。在这里，几何框架，一种状态空间营养建模方法，被用来测量饮食能量，蛋白质，脂肪和碳水化合物对食物摄入，心脏代谢表型和寿命的交互影响，老鼠随意喂食25种饮食之一。食物摄入主要受蛋白质和碳水化合物含量的调节。以碳水化合物代替蛋白质，限制蛋白质的代偿性喂养，抑制蛋白质的摄入，可优化寿命和健康。这些后果与哺乳动物肝脏雷帕霉素靶点（mTOR）激活和线粒体功能有关，反过来又与循环支链氨基酸和葡萄糖有关。通过高蛋白饮食或饮食稀释来限制卡路里对寿命没有有益影响。结果表明，通过控制常量营养素的比例来抑制mTOR的激活，可以延长自由喂养动物的寿命。
The fundamental questions of what represents a macronutritionally balanced diet and how this maintains health and longevity remain unanswered. Here, the Geometric Framework, a state-space nutritional modeling method, was used to measure interactive effects of dietary energy, protein, fat, and carbohydrate on food intake, cardiometabolic phenotype, and longevity in mice fed one of 25 diets ad libitum. Food intake was regulated primarily by protein and carbohydrate content. Longevity and health were optimized when protein was replaced with carbohydrate to limit compensatory feeding for protein and suppress protein intake. These consequences are associated with hepatic mammalian target of rapamycin (mTOR) activation and mitochondrial function and, in turn, related to circulating branched-chain amino acids and glucose. Calorie restriction achieved by high-protein diets or dietary dilution had no beneficial effects on lifespan. The results suggest that longevity can be extended in ad libitum-fed animals by manipulating the ratio of macronutrients to inhibit mTOR activation.
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影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
DOI：
10.1152/ajpendo.91000.2008
发表时间：
2009-12-01
影响因子：
5.1
作者：
Chotechuang, Nattida;Azzout-Marniche, Dalila;Tome, Daniel
通讯作者：
Tome, Daniel
影响因子：
6.9
作者：
Huang, Xin;Hancock, Dale P.;Simpson, Stephen J.
通讯作者：
Simpson, Stephen J.
影响因子：
29
作者：
Kapahi P;Chen D;Rogers AN;Katewa SD;Li PW;Thomas EL;Kockel L
通讯作者：
Kockel L
影响因子：
5.5
作者：
Larsen, Steen;Nielsen, Joachim;Hey-Mogensen, Martin
通讯作者：
Hey-Mogensen, Martin