Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats.
Selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats.
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DOI：
10.1155/2012/309494
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发表时间：
2012
影响因子：
3.1
通讯作者：
Garcia-Segura LM
中科院分区：
文献类型：
--
作者：
González-Burgos I;Rivera-Cervantes MC;Velázquez-Zamora DA;Feria-Velasco A;Garcia-Segura LM
一些选择性雌激素受体调节剂，如雷洛昔芬和他莫昔芬，在几种神经退行性疾病的实验模型中具有神经保护作用并减少脑炎症。此外，雷洛昔芬和他莫昔芬抵消雄性大鼠性腺激素剥夺引起的认知缺陷。在这项研究中，我们探讨了雷洛昔芬和他莫昔芬是否可以调节大鼠海马CA 1区锥体神经元树突棘的数量和几何形状。向年轻成年雄性大鼠注射雷洛昔芬（1 mg/kg）、他莫昔芬（1 mg/kg）或溶媒，并在注射后24 h处死。与溶剂处理动物相比，雷洛昔芬或他莫昔芬处理动物显示CA 1锥体神经元中树突棘的数密度增加。雷洛昔芬和他莫昔芬对棘的形态也有特异性影响。这些结果表明，雷洛昔芬和他莫昔芬可能会影响海马锥体神经元的信息处理，通过影响树突棘的数量和形状。
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.
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影响因子：
6.2
作者：
Cerciat, M.;Unkila, M.;Arevalo, M. -A.
通讯作者：
Arevalo, M. -A.
影响因子：
4.8
作者：
Barreto, George;Santos-Galindo, Maria;Garcia-Segura, Luis M.
通讯作者：
Garcia-Segura, Luis M.
影响因子：
5
作者：
Feng, YZ;Fratkins, JD;LeBlanc, MH
通讯作者：
LeBlanc, MH
影响因子：
2.5
作者：
González-Burgos, I;Alejandre-Gómez, M;Cervantes, M
通讯作者：
Cervantes, M
影响因子：
7.6
作者：
Cyr, M;Landry, M;Di Paolo, T
通讯作者：
Di Paolo, T