SARS-CoV-2 infection: the environmental endurance of the virus can be influenced by the increase of temperature.
SARS-CoV-2 infection: the environmental endurance of the virus can be influenced by the increase of temperature.
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DOI：
10.1016/j.cmi.2020.10.034
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
COVID-19 Study Group
中科院分区：
文献类型：
--
作者：
Magurano F;Baggieri M;Marchi A;Rezza G;Nicoletti L;COVID-19 Study Group
探讨温度升高是否会影响严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）的环境耐受性。将病毒接种在塑料表面上，并在20°C-25°C（室温; RT）和28°C（6月温度; JT）下平行地在预定时间点收获。通过Vero细胞上的TCID 50滴度检测样品。我们的研究结果证实了新出现的SARS-CoV-2的病原体传播是可能的：在塑料表面上，病毒在RT和JT下感染细胞的能力保留长达84小时，TCID 50病毒滴度分别为0.67和0.25 log 10。在RT下，在前24-36小时内观察到病毒滴度显著降低，从4 log 10 TCID 50降至3 log 10 TCID 50。在JT下，观察到更快的相同衰减（8 - 12小时），RT下通过D值确定的病毒灭活速率为24.74小时，JT下为12.21小时。这两个温度之间的显著差异表明，病毒活力可能受到环境温度的影响，炎热的季节可以降低COVID-19传播的可能性。
To evaluate whether the increase of temperature can influence the environmental endurance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Virus was inoculated on a plastic surface and harvested at predefined time-points in parallel at 20°C–25°C (room temperature; RT) and at 28°C (June temperature; JT). Samples were tested by TCID50 titres on Vero cells. Our results confirm that fomite transmission of the emerging SARS-CoV-2 is possible: the virus reserved its ability to infect cells for up to 84 hours at both RT and JT on a plastic surface, with TCID50 viral titres of 0.67 and 0.25 log10, respectively. At RT, an important reduction in the viral titre, from 4 log10 to 3 log10 TCID50, was observed during the first 24–36 hours. At JT, the same decay was observed more rapidly (between 8 and 12 hours), The rate of viral inactivation by D-value was 24.74 hours at RT and 12.21 hours at JT. This remarkable difference between the two temperatures suggests that virus vitality can be influenced by the environmental temperature and that the hot season could reduce the probability of COVID-19 transmission.
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