Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys.
Neural presbycusis at ultra-high frequency in aged common marmosets and rhesus monkeys.
复制标题
老年普通绒猴和恒河猴的超高频神经性老年性聋。
DOI：
10.18632/aging.202936
复制
发表时间：
2021-04-27
期刊：
影响因子：
--
通讯作者：
Tao Y
中科院分区：
文献类型：
--
作者：
Sun Z;Cheng Z;Gong N;Xu Z;Jin C;Wu H;Tao Y
人口老龄化和环境噪声导致了老年性耳聋的高发病率，也被称为年龄相关性听力损失(ARHL)。由于小鼠的寿命相对较短，小鼠模型一直不适合于确定老年性耳聋的发生机制和诊断方法。虽然常见的绒猴是一种非人类灵长类动物(NHP)，是研究年龄相关性疾病的理想动物模型，但其听觉频谱尚未得到系统的研究。38只不同年龄的恒河猴的听性脑干反应(ABR)结果表明，听功能与年龄相关。老年普通绒猴的听力损失开始于超高频(>；16 kHz)，然后扩展到更低的频率。尽管绒猴的ABR阈值和波幅随年龄的增长而恶化，但外毛细胞(OHC)功能在所有年龄段都保持稳定。螺旋神经节神经元(SGN)是听觉系统中的第一个听觉神经元，在老年普通绒猴中发现有明显的变性，表明神经变性导致了这些动物的老年性耳聋。同样，在另一种NHP恒河猴中也观察到了与年龄相关的ABR恶化而没有丧失OHC功能。这两种NHP的测听结果表明，NHP是研究ARHL的理想方法，神经性老年性耳聋可能在灵长类动物中普遍存在。
The aging of the population and environmental noise have contributed to high rates of presbycusis, also known as age-related hearing loss (ARHL). Because mice have a relatively short life span, murine models have not been suitable for determining the mechanism of presbycusis development and methods of diagnosis. Although the common marmoset, a non-human primate (NHP), is an ideal animal model for studying age-related diseases, its auditory spectrum has not been systematically studied. Auditory brainstem responses (ABRs) from 38 marmosets of different ages demonstrated that auditory function correlated with age. Hearing loss in geriatric common marmosets started at ultra-high frequency (>16 kHz), then extended to lower frequencies. Despite age-related deterioration of ABR threshold and amplitude in marmosets, outer hair cell (OHC) function remained stable at all ages. Spiral ganglion neurons (SGNs), which are the first auditory neurons in the auditory system, were found to degenerate distinctly in aged common marmosets, indicating that neural degeneration caused presbycusis in these animals. Similarly, age-associated ABR deterioration without loss of OHC function was observed in another NHP, rhesus monkeys. Audiometry results from these two species of NHP suggested that NHPs were ideal for studying ARHL and that neural presbycusis at high frequency may be prevalent in primates.
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DOI：
10.1111/febs.15341
发表时间：
2021-01
期刊：
The FEBS journal
影响因子：
--
作者：
Hosoya M;Fujioka M;Murayama AY;Okano H;Ogawa K
通讯作者：
Ogawa K
影响因子：
1.9
作者：
BENNETT, CL;DAVIS, RT;MILLER, JM
通讯作者：
MILLER, JM
DOI：
10.1111/j.1749-6632.2010.05609.x
发表时间：
2010-01-01
期刊：
REPRODUCTIVE AGING
影响因子：
--
作者：
Austad, Steven N.
通讯作者：
Austad, Steven N.
影响因子：
2.8
作者：
Fowler, Cynthia G.;Chiasson, Kirstin Beach;Leslie, Tami Hanson;Thomas, Denise;Beasley, T. Mark;Kemnitz, Joseph W.;Weindruch, Richard
通讯作者：
Weindruch, Richard
小鼠耳蜗 Sox2 支持细胞中与年龄相关的转录组变化。
影响因子：
7.5
作者：
Cheng, Cheng;Wang, Yunfeng;Chai, Renjie
通讯作者：
Chai, Renjie