Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?
Infralimbic cortex functioning across motivated behaviors: Can the differences be reconciled?
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DOI：
10.1016/j.neubiorev.2021.10.002
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发表时间：
2021-12
影响因子：
8.2
通讯作者：
LaLumiere RT
中科院分区：
文献类型：
--
作者：
Nett KE;LaLumiere RT
啮齿动物的边缘下皮层（IL）参与高级执行功能，如奖励寻求和灵活的决策。然而，其在这些过程中的作用的确切性质尚不清楚。早期的证据表明，IL促进恐惧条件反射和可卡因寻求的消退和持续抑制。然而，跨越其他行为领域的证据，如自然奖励寻求和基于习惯的学习，表明对IL功能有更细致的理解。随着技术的进步和更多的研究已经检查了IL功能，确定其行为功能的统一解释变得越来越困难。在这里，我们讨论了IL功能的动机行为，包括联想学习，药物寻求，自然奖励寻求，目标导向与习惯为基础的行为的证据，并强调如何上下文特定的编码和异质IL神经元群体可能在文献中看似矛盾的结果。总之，证据表明，IL的主要功能是促进线索和行为之间的偶然性的编码和更新，以指导随后的行为。
The rodent infralimbic cortex (IL) is implicated in higher order executive functions such as reward seeking and flexible decision making. However, the precise nature of its role in these processes is unclear. Early evidence indicated that the IL promotes the extinction and ongoing inhibition of fear conditioning and cocaine seeking. However, evidence spanning other behavioral domains, such as natural reward seeking and habit-based learning, suggests a more nuanced understanding of IL function. As techniques have advanced and more studies have examined IL function, identifying a unifying explanation for its behavioral function has become increasingly difficult. Here, we discuss evidence of IL function across motivated behaviors, including associative learning, drug seeking, natural reward seeking, and goal-directed versus habit-based behaviors, and emphasize how context-specific encoding and heterogeneous IL neuronal populations may underlie seemingly conflicting findings in the literature. Together, the evidence suggests that a major IL function is to facilitate the encoding and updating of contingencies between cues and behaviors to guide subsequent behaviors.
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