Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes.

Accumulation of Immunity in Heavy-Tailed Sexual Contact Networks Shapes Mpox Outbreak Sizes.
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DOI:
10.1093/infdis/jiad254
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发表时间:
2024-01-12
影响因子:
6.4
通讯作者:
Endo, Akira
Endo, Akira
中科院分区:
医学2区
文献类型:
--
作者:
Murayama, Hiroaki;Pearson, Carl A. B.;Abbott, Sam;Miura, Fuminari;Jung, Sung-mok;Fearon, Elizabeth;Funk, Sebastian;Endo, Akira

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受2022年全球爆发天花疫情影响的许多国家都观察到病例下降。我们的数学模型解释了厚尾性伙伴关系分布,表明天花流行可以达到感染衍生的群体免疫阈值,并开始下降,无论干预或行为改变如何,与男性发生性关系的性活跃男性中只有<1%的人感染。我们一致发现,许多国家和美国各州都经历了疫情高峰,在男男性行为者中累积病例约为0.1%至0.5%。观察到的病例减少可能不一定主要归因于干预措施或行为变化。在与男性发生性关系的男性中,感染源性免疫在高度异质性的性接触网络中的积累可以合理地解释2022年观察到的天花病例下降,而无需假设干预措施或行为变化的影响。
Many countries affected by the global outbreak of mpox in 2022 have observed a decline in cases. Our mathematical model accounting for heavy-tailed sexual partnership distributions suggests that mpox epidemics can hit the infection-derived herd immunity threshold and begin to decline, with <1% of sexually active men who have sex with men infected regardless of interventions or behavioral changes. We consistently found that many countries and US states experienced an epidemic peak, with cumulative cases of around 0.1% to 0.5% among men who have sex with men. The observed decline in cases may not necessarily be attributable to interventions or behavioral changes primarily. Accumulation of infection-derived immunity in highly heterogeneous sexual contact networks among men who have sex with men could plausibly explain the observed decline in mpox cases in 2022 without needing to assume impacts of interventions or behavioral changes.
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