8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats
8-OH-DPAT enhances dopamine D2-induced maternal disruption in rats
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8-OH-DPAT 增强多巴胺 D2 诱导的大鼠母体破坏
DOI：
10.1007/s00359-022-01551-4
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Ruiyong Wu
中科院分区：
文献类型：
--
作者：
Yongjian Cai;Xinyue Zhang;Tianyi Jiang;Haocheng Zhong;Xingchen Han;Rui Ma;Ruiyong Wu
最近的证据表明，5-HT1A受体在调节大鼠的母性行为中起着重要作用。鉴于它们还调节中皮质多巴胺系统，我们假设5-HT1A受体可能通过与D2受体相互作用来调节母亲的行为。为了解决这个问题，我们在家庭笼子里的母体行为和幼崽偏好测试中，使用了5-HT1受体激动剂(8-OH-DPAT，0.5 mg/kg)和两种D2药物(激动剂奎比罗，Quin，1.0 mg/kg；D2拮抗剂氟哌啶醇，HAL，0.1 mg/kg)的组合来抑制大鼠的母性行为。我们重复了这一发现，即急性Quin、HAL和8-OH-DPAT扰乱了家庭笼子里的母亲行为。当HAL和Quin联合给药时，HAL和Quin的预处理加剧了8-OH-DPAT引起的母体分裂，并导致幼崽偏好率下降。相应地，8-OH-DPAT增强了Quin‘和HAL对幼崽取回和幼崽偏好的干扰，逆转了HAL引起的幼崽悬停增加。这些发现表明，5-HT1A受体的激活加强了D2介导的母体干扰。此外，鉴于D2药物和5-HT1受体激动剂的组合只对母体干扰产生相加作用，5-HT1受体可能独立于它们与D2受体的相互作用而对母体行为产生直接影响。
Recent evidence indicates that 5-HT1Areceptors play a significant role in mediating maternal behavior in rats. Given that they also modulate the mesocortical dopamine system, we hypothesized that 5-HT1Areceptors may mediate maternal behavior, possibly by interacting with the D2receptor. To address this issue, we used a combination of 5-HT1Aagonist (8-OH-DPAT, 0.5 mg/kg) and two D2drugs (an agonist quinpirole, QUIN, 1.0 mg/kg; a potent D2antagonist haloperidol, HAL, 0.1 mg/kg) on rat maternal behavior in the home-cage maternal behavior and pup preference tests. We replicated the findings that acute QUIN, HAL, and 8-OH-DPAT disrupted home-cage maternal behavior. When administered in combination, pretreatment with HAL and QUIN worsened 8-OH-DPAT-induced maternal disruption and induced a decrease in the pup preference ratio. Accordingly, 8-OH-DPAT enhanced QUIN’ and HAL’s disruption of pup retrieval and pup preference, reversed the increase in hovering over pups induced by HAL. These findings suggest that activation of 5-HT1Areceptors enhances D2-mediated maternal disruption. Furthermore, given that the combination of D2drugs and 5-HT1Aagonists only produced an additive effect on maternal disruption, 5-HT1Areceptors may have a direct effect on maternal behavior independent of their interaction with D2receptors.
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影响因子：
4.5
作者：
Li, M;Davidson, P;Fleming, AS
通讯作者：
Fleming, AS
DOI：
10.1007/bf01244451
发表时间：
2005
期刊：
Journal of Neural Transmission / General Section JNT
影响因子：
--
作者：
M. Wadenberg;S. Ahlénius
通讯作者：
M. Wadenberg;S. Ahlénius
影响因子：
3.4
作者：
Garcia-Garcia, Alvaro L.;Newman-Tancredi, Adrian;Leonardo, E. David
通讯作者：
Leonardo, E. David
影响因子：
1.6
作者：
Alkhatib, Ahmad H.;Dvorkin-Gheva, Anna;Szechtman, Henry
通讯作者：
Szechtman, Henry
影响因子：
3.6
作者：
Zhao, Changjiu;Li, Ming
通讯作者：
Li, Ming