Sensory input attenuation allows predictive sexual response in yeast.
Sensory input attenuation allows predictive sexual response in yeast.
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DOI：
10.1038/ncomms12590
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发表时间：
2016-08-25
影响因子：
16.6
通讯作者：
Sourjik, Victor
中科院分区：
文献类型：
--
作者：
Banderas, Alvaro;Koltai, Mihaly;Anders, Alexander;Sourjik, Victor
众所周知，动物会根据配偶竞争来调整它们的性行为。在这里，我们报告了类似的调节交配行为的有性单细胞真核生物，芽殖酵母酿酒酵母。我们表明，两种交配类型之间的信息素为基础的通信，再加上输入衰减受体细胞，使酵母菌稳健地监测相对交配丰度（性别比）内的混合人口，并调整他们的承诺，有性生殖的比例，他们估计成功交配的机会。性比感应的机制依赖于可扩散的肽酶Bar1，它被称为降解交配伴侣产生的信息素信号。我们进一步表明，对群体内性竞争的这种反应可以优化交配反应诱导的成本和收益之间的适应性权衡。因此，我们的研究提供了一个适应性的解释，已知的分子机制的信息素降解酵母。 酿酒酵母的细胞可以与相反交配类型的其他细胞交配。在这里，作者表明，信息素和信息素降解酶的组合允许酵母细胞监测种群内的相对配偶丰度，并调整它们对有性生殖的承诺。
Animals are known to adjust their sexual behaviour depending on mate competition. Here we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the budding yeast Saccharomyces cerevisiae. We demonstrate that pheromone-based communication between the two mating types, coupled to input attenuation by recipient cells, enables yeast to robustly monitor relative mate abundance (sex ratio) within a mixed population and to adjust their commitment to sexual reproduction in proportion to their estimated chances of successful mating. The mechanism of sex-ratio sensing relies on the diffusible peptidase Bar1, which is known to degrade the pheromone signal produced by mating partners. We further show that such a response to sexual competition within a population can optimize the fitness trade-off between the costs and benefits of mating response induction. Our study thus provides an adaptive explanation for the known molecular mechanism of pheromone degradation in yeast. Cells of the yeast Saccharomyces cerevisiae can mate with other cells of opposite mating type. Here, the authors show that the combination of a pheromone and a pheromone-degrading enzyme allows yeast cells to monitor relative mate abundance within a population and adjust their commitment to sexual reproduction.
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影响因子：
9.9
作者：
Houser, John R.;Ford, Eintou;Nagiec, Michal J.;Errede, Beverly;Elston, Timothy C.
通讯作者：
Elston, Timothy C.
影响因子：
5.3
作者：
HAGEN, DC;MCCAFFREY, G;SPRAGUE, GF
通讯作者：
SPRAGUE, GF
DOI：
10.1098/rsbl.2003.0083
发表时间：
2004-02-07
影响因子：
4.7
作者：
Greig, D;Travisano, M
通讯作者：
Travisano, M
影响因子：
64.8
作者：
Foster, KR;Shaulsky, G;Thompson, CRL
通讯作者：
Thompson, CRL
在细胞内信号网络中，剂量到延伸的编码和信号超出饱和度。
影响因子：
4.3
作者：
Behar, Marcelo;Hao, Nan;Dohlman, Henrik G.;Elston, Timothy C.
通讯作者：
Elston, Timothy C.