Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers.
Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers.
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DOI：
10.3390/vaccines9101092
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发表时间：
2021-09-28
期刊：
影响因子：
7.8
通讯作者：
Favresse J
中科院分区：
文献类型：
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作者：
Bayart JL;Douxfils J;Gillot C;David C;Mullier F;Elsen M;Eucher C;Van Eeckhoudt S;Roy T;Gerin V;Wieers G;Laurent C;Closset M;Dogné JM;Favresse J
关于SARS-CoV-2疫苗接种后抗体长期持续时间的数据仍然很少，这对设计疫苗接种策略很重要。在这项研究中，231名医疗保健专业人员接受了BNT 162 b2的两剂方案。其中，基线时158例为血清阴性，73例为血清阳性。在几个时间点收集样品。检测SARS-CoV-2的中和抗体（NAb）、核衣壳抗体和刺突蛋白抗体。在第180天，在血清阴性（总抗体测定为−55.4%; IgG测定为−89.6%）和血清阳性个体（总抗体测定为−74.8%; IgG测定为−79.4%）中观察到抗体显著下降。在血清阴性个体中，来自峰值体液应答的IgG的估计半衰期为21天（95% CI：13-65），在血清阳性个体中为53天（95% CI：40-79）。血清阳性和血清阴性个体中总抗体的估计半衰期较长，范围分别为68天（95% CI：54-90）至114天（95% CI：87-167）。NAb的下降更为明显（-98.6%），约45%的受试者在第180天呈阴性。这种下降是否与抗病毒临床有效性的同等下降相关，需要进行适当的临床研究。
Data about the long-term duration of antibodies after SARS-CoV-2 vaccination are still scarce and are important to design vaccination strategies. In this study, 231 healthcare professionals received the two-dose regimen of BNT162b2. Of these, 158 were seronegative and 73 were seropositive at baseline. Samples were collected at several time points. The neutralizing antibodies (NAbs) and antibodies against the nucleocapsid and the spike protein of SARS-CoV-2 were measured. At day 180, a significant antibody decline was observed in seronegative (−55.4% with total antibody assay; −89.6% with IgG assay) and seropositive individuals (−74.8% with total antibody assay; −79.4% with IgG assay). The estimated half-life of IgG from the peak humoral response was 21 days (95% CI: 13–65) in seronegative and 53 days (95% CI: 40–79) in seropositive individuals. The estimated half-life of total antibodies was longer and ranged from 68 days (95% CI: 54–90) to 114 days (95% CI: 87–167) in seropositive and seronegative individuals, respectively. The decline of NAbs was more pronounced (−98.6%) and around 45% of the subjects tested were negative at day 180. Whether this decrease correlates with an equivalent drop in the clinical effectiveness against the virus would require appropriate clinical studies.
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影响因子：
82.9
作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
通讯作者：
Kishony, Roy
影响因子：
82.9
作者：
Ebinger JE;Fert-Bober J;Printsev I;Wu M;Sun N;Prostko JC;Frias EC;Stewart JL;Van Eyk JE;Braun JG;Cheng S;Sobhani K
通讯作者：
Sobhani K
DOI：
10.1016/j.cmi.2021.01.005
发表时间：
2021-01-20
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
L'Huillier AG;Meyer B;Andrey DO;Arm-Vernez I;Baggio S;Didierlaurent A;Eberhardt CS;Eckerle I;Grasset-Salomon C;Huttner A;Posfay-Barbe KM;Royo IS;Pralong JA;Vuilleumier N;Yerly S;Siegrist CA;Kaiser L;Geneva Centre for Emerging Viral Diseases
通讯作者：
Geneva Centre for Emerging Viral Diseases
影响因子：
2.7
作者：
Jung K;Shin S;Nam M;Hong YJ;Roh EY;Park KU;Song EY
通讯作者：
Song EY
DOI：
10.1056/nejmoa2109072
发表时间：
2021-10-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bergwerk M;Gonen T;Lustig Y;Amit S;Lipsitch M;Cohen C;Mandelboim M;Levin EG;Rubin C;Indenbaum V;Tal I;Zavitan M;Zuckerman N;Bar-Chaim A;Kreiss Y;Regev-Yochay G
通讯作者：
Regev-Yochay G