Late Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children.
Late Eating Is Associated with Obesity, Inflammatory Markers and Circadian-Related Disturbances in School-Aged Children.
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DOI：
10.3390/nu12092881
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发表时间：
2020-09-21
期刊：
影响因子：
5.9
通讯作者：
Garaulet M
中科院分区：
文献类型：
--
作者：
Martínez-Lozano N;Tvarijonaviciute A;Ríos R;Barón I;Scheer FAJL;Garaulet M
晚吃已被证明会促进代谢失调，并与成人肥胖有关。然而，很少有研究在儿童中探索这种联系。我们比较了学龄儿童中晚餐早吃者（EDE）和晚餐晚吃者（LDE）的肥胖、代谢改变和昼夜节律相关紊乱的存在。根据晚餐时间（中位数：21：07），将来自西班牙的学龄儿童（n = 397; 8-12岁;平均BMI（范围）：19.4 kg/m2（11.6-35.1）; 30.5%超重/肥胖）分为EDE和LDE。7天饮食记录用于评估食物时间和组成。使用非侵入性工具收集代谢生物标志物（唾液），睡眠和昼夜节律相关变量（体温和活动记录）。与EDE相比，LDE更可能超重/肥胖[OR：2.1（CI：1.33，3.31）; p = 0.002]，腰围和炎症标志物，如IL-6（1.6倍）（p = 0.036）和CRP（1.4倍）高于EDE（p = 0.009）。LDE改变了每日模式：（a）体温，相位延迟26分钟（p = 0.002），振幅降低（LDE = 0.028（0.001）和EDE = 0.030（0.001）（平均值（SEM）; p = 0.039）;（B）皮质醇，幅度降低（LDE = 0.94（0.02）和EDE = 1.00（0.02）; p = 0.035）。这项研究代表了对儿童食物摄入时间的新方面的理解的重要一步。
Late eating has been shown to promote metabolic dysregulation and to be associated with obesity in adults. However, few studies have explored this association in children. We compared the presence of obesity, metabolic alterations and circadian-related disturbances between school-aged children who were early dinner eaters (EDE) or late dinner eaters (LDE). School-age children (n = 397; 8–12 years; mean BMI (range): 19.4 kg/m2 (11.6–35.1); 30.5% overweight/obesity) from Spain were classified into EDE and LDE, according to dinner timing (Median: 21:07). Seven-day-dietary-records were used to assess food-timing and composition. Non-invasive tools were used to collect metabolic biomarkers (saliva), sleep and circadian-related variables (body-temperature and actigraphy). Compared to EDE, LDE were more likely to be overweight/obese [OR: 2.1 (CI: 1.33, 3.31); p = 0.002], and had higher waist-circumference and inflammatory markers, such as IL-6 (1.6-fold) (p = 0.036)) and CRP (1.4-fold) than EDE (p = 0.009). LDE had alterations in the daily patterns of: (a) body-temperature, with a phase delay of 26 min (p = 0.002), and a reduced amplitude (LDE = 0.028 (0.001) and EDE = 0.030 (0.001) (Mean (SEM); p = 0.039); (b) cortisol, with a reduced amplitude (LDE = 0.94 (0.02) and EDE = 1.00 (0.02); p = 0.035). This study represents a significant step towards the understanding of novel aspects in the timing of food intake in children.
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影响因子：
6.3
作者：
Maria Barraco, Gloria;Martinez-Lozano, Nuria;Garaulet, Marta
通讯作者：
Garaulet, Marta
影响因子：
4.3
作者：
Cardoso Lopes, Tassia do Vale;Borba, Matheus Eduardo;Crispim, Cibele Aparecida
通讯作者：
Crispim, Cibele Aparecida
影响因子：
1.8
作者：
Azevedo, Carolina V. M.;Sousa, Ivanise;Antonio Madrid, Juan
通讯作者：
Antonio Madrid, Juan
影响因子：
7.1
作者：
McHill, Andrew W.;Phillips, Andrew J. K.;Klerman, Elizabeth B.
通讯作者：
Klerman, Elizabeth B.
DOI：
10.1016/j.clnu.2017.04.003
发表时间：
2018-08
期刊：
Clinical nutrition (Edinburgh, Scotland)
影响因子：
--
作者：
Lopez-Minguez J;Saxena R;Bandín C;Scheer FA;Garaulet M
通讯作者：
Garaulet M