Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria.
Cuprous oxide nanoparticles inhibit the growth and metastasis of melanoma by targeting mitochondria.
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氧化亚铜纳米颗粒通过靶向线粒体抑制黑色素瘤的生长和转移。
DOI：
10.1038/cddis.2013.314
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发表时间：
2013-08-29
影响因子：
9
通讯作者：
中科院分区：
文献类型：
--
作者：
金属及其氧化物纳米粒子显示出理想的药理活性，尤其是在抗肿瘤治疗方面。我们的前期研究表明，氧化亚铜纳米颗粒（CONPs）在体外可选择性诱导肿瘤细胞凋亡。为了探索C 0 NP在体内的抗肿瘤特性，我们使用颗粒分别通过瘤内和全身注射来治疗基于B16-F10小鼠黑素瘤细胞的小鼠皮下黑素瘤和转移性肺肿瘤。结果表明，CONP能显著抑制黑色素瘤的生长，抑制B16-F10细胞的转移，提高荷瘤小鼠的生存率。重要的是，结果还表明CONP可迅速从器官中清除，并且这些颗粒几乎没有表现出全身毒性。此外，我们观察到CONP靶向线粒体，这导致细胞色素C从线粒体释放，并在CONP进入细胞后激活caspase-3和caspase-9。总之，CONP可以通过一个peptide介导的凋亡途径诱导癌细胞凋亡，这增加了CONP可用于治疗黑色素瘤和其他癌症的可能性。
Metal and its oxide nanoparticles show ideal pharmacological activity, especially in anti-tumor therapy. Our previous study demonstrated that cuprous oxide nanoparticles (CONPs) selectively induce apoptosis of tumor cells in vitro. To explore the anti-tumor properties of CONPs in vivo, we used the particles to treat mouse subcutaneous melanoma and metastatic lung tumors, based on B16-F10 mouse melanoma cells, by intratumoral and systemic injections, respectively. The results showed that CONPs significantly reduced the growth of melanoma, inhibited the metastasis of B16-F10 cells and increased the survival rate of tumor-bearing mice. Importantly, the results also indicated that CONPs were rapidly cleared from the organs and that these particles exhibited little systemic toxicity. Furthermore, we observed that CONPs targeted the mitochondria, which resulted in the release of cytochrome C from the mitochondria and the activation of caspase-3 and caspase-9 after the CONPs entered the cells. In conclusion, CONPs can induce the apoptosis of cancer cells through a mitochondrion-mediated apoptosis pathway, which raises the possibility that CONPs could be used to cure melanoma and other cancers.
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影响因子：
41.2
作者：
通讯作者：
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在致癌 BRAF 诱导的黑色素瘤小鼠模型中体内鉴定肿瘤抑制性 PTEN ceRNA。
影响因子：
64.5
作者：
Karreth FA;Tay Y;Perna D;Ala U;Tan SM;Rust AG;DeNicola G;Webster KA;Weiss D;Perez-Mancera PA;Krauthammer M;Halaban R;Provero P;Adams DJ;Tuveson DA;Pandolfi PP
通讯作者：
Pandolfi PP
DOI：
10.1016/j.nano.2012.01.009
发表时间：
2012-10-01
影响因子：
5.4
作者：
Guan, Min;Zhou, Yi;Zhang, Qiang
通讯作者：
Zhang, Qiang
影响因子：
3.8
作者：
Kim, Ki-Tae;Zaikova, Tatiana;Tanguay, Robert L.
通讯作者：
Tanguay, Robert L.
影响因子：
5.8
作者：
Jeyaraj, Murugaraj;Rajesh, Manoharan;Ganapathi, Andy
通讯作者：
Ganapathi, Andy