Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia.
Correlations between exploratory eye movement, hallucination, and cortical gray matter volume in people with schizophrenia.
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精神分裂症患者探索性眼球运动、幻觉和皮质灰质体积之间的相关性
DOI：
10.1186/s12888-018-1806-8
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发表时间：
2018-07-13
期刊：
影响因子：
4.4
通讯作者：
Zhang D
中科院分区：
文献类型：
--
作者：
Qiu L;Yan H;Zhu R;Yan J;Yuan H;Han Y;Yue W;Tian L;Zhang D
精神分裂症患者广泛的皮质灰质改变与精神病症状和认知/行为异常相关，包括探索性眼球运动（EEM）的障碍。特别是，灰质密度的损失是特别相关的缺陷的EEM的响应搜索得分（RSS）的精神分裂症。然而，尚不清楚精神分裂症相关的RSS缺陷是否与某些精神病症状（如幻觉）有关。对33例精神分裂症患者进行EEM测量、阳性和阴性症状量表（PANSS）评定幻觉严重程度和基于体素的脑灰质体积（GMV）形态计量学分析，以探讨EEM的RSS、症状严重程度和GMV之间的关系。在29名匹配的健康对照者中，还进行了EEM的测量和基于体素的皮质GMV的形态计量学分析，以探讨EEM的RSS与GMV之间的关系。在精神分裂症患者中，幻觉的严重程度与额叶、颞叶、顶叶、眶额、距状核、扣带回和岛叶皮质、罗兰岛盖、海马、海马旁回和丘脑中大量脑区的RSS和GMV呈显著负相关。同样在精神分裂症患者中，RSS与左侧补充运动区（SMA）、左侧上级额叶皮质（SFG）、双侧中央前回、双侧中央后回和双侧额中皮质的GMV显著正相关。更重要的是，SMA，SFG和中央前回的GMV不仅与幻觉的严重程度呈显著负相关，而且与RSS呈显著正相关。在健康对照组的任何脑区的RSS和GMV之间没有显着的相关性。幻觉严重程度与EEM的RSS呈显著负相关，提示RSS可能是预测精神分裂症幻觉严重程度的潜在生物标志物。此外，左侧SMA、SFG和中央前回的GMV可能是精神分裂症患者幻觉诱导和RSS的共同基础。本文的在线版本（10.1186/s12888-018-1806-8）包含补充材料，可供授权用户使用。
Widespread cortical gray matter alternations in people with schizophrenia are correlated with both psychotic symptoms and cognitive/behavioral abnormalities, including the impairments of exploratory eye movement (EEM). Particularly, the loss of gray matter density is specifically related to deficits of the responsive search score (RSS) of EEM in schizophrenia. It is unknown, however, whether the schizophrenia-related RSS deficits are associated with certain psychotic symptoms, such as hallucinations. In 33 participants with schizophrenia, the measurement of EEM, assessment of the hallucination severity using Positive and Negative Syndrome Scale (PANSS) and a voxel-based morphometric analysis of cortical gray matter volume (GMV) were conducted to investigate the relationships between the RSS of EEM, symptom severity, and GMV. In 29 matched healthy controls, the measurement of EEM and a voxel-based morphometric analysis of cortical GMV were also conducted to investigate the relationship between the RSS of EEM and GMV. In participants with schizophrenia, the hallucination severity was significantly negatively correlated with both the RSS and the GMV of a large number of brain regions in the frontal, temporal, parietal, orbitofrontal, calcarine, cingulate, and insular cortices, and rolandic operculum, hippocampus, parahippocampal gyrus, and thalamus. Also in participants with schizophrenia, the RSS was significantly positively correlated with the GMV in the left supplementary motor area (SMA), left superior frontal cortex (SFG), bilateral precentral gyri, bilateral postcentral gyri, and bilateral middle frontal cortices. More importantly, the GMV of the SMA, SFG, and precentral gyrus in the left hemisphere was not only significantly negatively correlated with the hallucination severity but also significantly positively correlated with the RSS. No significant correlation could be revealed between the RSS and the GMV of any brain regions in healthy controls. There was a significantly negative association between the hallucination severity and the RSS of EEM, suggesting that the RSS may be a potential biomarker for predicting the hallucination severity of schizophrenia. Also, the GMV of the left SMA, SFG, and precentral gyrus may be the common substrates underlying both hallucination induction and the RSS in people with schizophrenia. The online version of this article (10.1186/s12888-018-1806-8) contains supplementary material, which is available to authorized users.
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