Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction.
Association of serum angiopoietin-1, angiopoietin-2 and angiopoietin-2 to angiopoietin-1 ratio with heart failure in patients with acute myocardial infarction.
复制标题
急性心肌梗死患者血清血管生成素1、血管生成素2及血管生成素2与血管生成素1比值与心力衰竭的关系
DOI：
10.3892/etm.2013.893
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发表时间：
2013-03
影响因子：
2.7
通讯作者：
Cui M
中科院分区：
文献类型：
--
作者：
Chen S;Guo L;Chen B;Sun L;Cui M
The aim of the present study was to investigate the association of the serum angiopoietin (Ang)-1 and Ang-2 levels and the Ang-2 to Ang-1 ratio (Ang-2/Ang-1) with heart failure (HF) in patients with acute myocardial infarction (AMI) during hospitalization. The serum Ang-1 and Ang-2 levels of the AMI patients were measured at admission to hospital. The correlations between serum Ang-1, Ang-2 and Ang-2/Ang-1 with HF were examined. Among 103 patients, 20 developed HF during hospitalization. The serum Ang-2 level and Ang-2/Ang-1 were found to be significantly higher in the patients with HF than in the patients without HF (2,203.1±122.0 vs. 2,102.3±114.4 pg/ml, P=0.001 and 11.4±1.6×10−2 vs. 10.6±1.1×10−2, P=0.007, respectively). Serum Ang-2 level and Ang-2/Ang-1 were negatively correlated with left ventricular ejection fraction (LVEF; r=−0.352, P<0.001 and r=−0.365, P<0.001, respectively) and positively correlated with the natural logarithm of the level of N-terminal pro-B-type natriuretic peptide (LnNT-proBNP, r=0.367, P<0.001 and r=0.304, P=0.003, respectively) and peak cardiac troponin T (cTnT, r=0.421, P<0.001 and r=0.278, P=0.009, respectively). However, the serum Ang-1 level was not found to correlate significantly with LVEF (r= 0.194, P= 0.05), LnNT-proBNP (r=−0.116, P=0.266) or peak cTnT (r=−0.056, P=0.607). In multivariable logistic regression analysis, Ang-2 (P=0.031), Ang-2/Ang-1 (P=0.018) and NT-proBNP (P=0.001) were revealed to be independently associated with HF. The present study reveals that Ang-2 levels and Ang-2/Ang-1 are independent predictors of HF in AMI patients during hospitalization.
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影响因子：
2.1
作者：
Iribarren C;Phelps BH;Darbinian JA;McCluskey ER;Quesenberry CP;Hytopoulos E;Vogelman JH;Orentreich N
通讯作者：
Orentreich N
影响因子：
6.8
作者：
Buchner, Stefan;Debl, Kurt;Luchner, Andreas
通讯作者：
Luchner, Andreas
DOI：
10.1016/j.bbrc.2010.06.062
发表时间：
2010-07-23
影响因子：
3.1
作者：
Chen, Jingzhou;Yu, Hui;Hui, Rutai
通讯作者：
Hui, Rutai
影响因子：
37.8
作者：
Lee, KW;Lip, GYH;Blann, AD
通讯作者：
Blann, AD
影响因子：
16.2
作者：
Lim, HS;Blann, AD;Lip, GYH
通讯作者：
Lip, GYH