Stimulus train duration but not attention moderates γ-band entrainment abnormalities in schizophrenia.
Stimulus train duration but not attention moderates γ-band entrainment abnormalities in schizophrenia.
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刺激训练持续时间，但没有注意力减轻精神分裂症的γ波段夹带异常。
DOI：
10.1016/j.schres.2015.02.016
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发表时间：
2015-06
影响因子：
4.5
通讯作者：
Clementz BA
中科院分区：
文献类型：
--
作者：
Hamm JP;Bobilev AM;Hayrynen LK;Hudgens-Haney ME;Oliver WT;Parker DA;McDowell JE;Buckley PA;Clementz BA
Electroencephalographic (EEG) studies of auditory steady-state responses (aSSRs) non-invasively probe gamma-band (40-Hz) oscillatory capacity in sensory cortex with high signal-to-noise ratio. Consistent reports of reduced 40-Hz aSSRs in persons with schizophrenia (SZ) indicate its potential as an efficient biomarker for the disease, but studies have been limited to passive or indirect listening contexts with stereotypically short (500ms) stimulus trains. An inability to modulate sensorineural processing in accord with behavioral goals or within the sensory environmental context may represent a fundamental deficit in SZ, but whether and how this deficit relates to reduced aSSRs is unknown. We systematically varied stimulus duration and attentional contexts to further mature the 40-Hz aSSR as biomarker for future translational or mechanistic studies. Eighteen SZ and 18 healthy subjects (H) were presented binaural pure-tones with or without sinusoidal amplitude modulation at 40-Hz. Stimulus duration (500-ms or 1500-ms) and attention (via a button press task) were varied across 4 separate blocks. Evoked potentials recorded with dense-array EEGs were analyzed in the time-frequency domain. SZ displayed reduced 40-Hz aSSRs to typical stimulation parameters, replicating previous findings. In H, aSSRs were reduced when stimuli were presented in longer trains and were slightly enhanced by attention. Only the former modulation was impaired in SZ and correlated with sensory discrimination performance. Thus, gamma-band aSSRs are modulated by both attentional and stimulus duration contexts, but only modulations related to physical stimulus properties are abnormal in SZ, supporting its status as a biomarker of psychotic perceptual disturbance involving non-attentional sensori-cortical circuits.
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DOI：
10.1016/j.cogbrainres.2005.01.020
发表时间：
2005-07-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Gilmore, CS;Clementz, BA;Buckley, PF
通讯作者：
Buckley, PF
影响因子：
3
作者：
Basar-Eroglu, Canan;Brand, Andreas;Schmiedt, Christina
通讯作者：
Schmiedt, Christina
影响因子：
2
作者：
Clementz, BA;Blumenfeld, LD
通讯作者：
Blumenfeld, LD
影响因子：
10.6
作者：
Kirihara, Kenji;Rissling, Anthony J.;Swerdlow, Neal R.;Braff, David L.;Light, Gregory A.
通讯作者：
Light, Gregory A.
DOI：
10.1176/appi.ajp.2014.13121691
发表时间：
2015-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Javitt DC;Freedman R
通讯作者：
Freedman R