A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence.
A prospective investigation of fish, meat and cooking-related carcinogens with endometrial cancer incidence.
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DOI：
10.1038/bjc.2013.252
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发表时间：
2013-08-06
影响因子：
8.8
通讯作者：
Sinha R
中科院分区：
文献类型：
--
作者：
Arem H;Gunter MJ;Cross AJ;Hollenbeck AR;Sinha R
关于鱼和肉的摄入量与子宫内膜癌风险的前瞻性研究有限，研究结果并不一致。我们在大型、前瞻性的美国国立卫生研究院饮食与健康研究中研究了鱼和肉的摄入量与子宫内膜癌发病率的关系。肉类诱变剂2-amino-1-methyl-6-phenylimidazo[4，5-b]pyridine(PhIP)、2-氨基-3，8-二甲基咪唑并[4，5-f]喹恶啉(MeIQx)、2-amino-3，4，8-trimethylimidazo[4，5-f]quinoxaline(DiMeIQx)和苯并(A)芘(BaP)的摄入量也被计算出来。我们使用COX比例风险回归模型估计危险比(HR)和95%可信区间(CI)。红肉(HR=0.91，95%CI为0.77-1.08)、白肉(0.98，0.83-1.17)、加工肉(1.02，0.86-1.21)和鱼肉(1.10，95%CI为0.93-1.29)的摄入量与子宫内膜癌风险无相关性。我们也没有发现肉类诱变剂摄入量与子宫内膜癌之间的关系。我们的发现不支持肉类或鱼类摄入量或肉类诱变剂与子宫内膜癌之间的联系。
There are limited prospective studies of fish and meat intakes with risk of endometrial cancer and findings are inconsistent. We studied associations between fish and meat intakes and endometrial cancer incidence in the large, prospective National Institutes of Health-AARP Diet and Health Study. Intakes of meat mutagens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (DiMeIQx) and benzo(a)pyrene (BaP) were also calculated. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). We observed no associations with endometrial cancer risk comparing the highest to lowest intake quintiles of red (HR=0.91, 95% CI 0.77–1.08), white (0.98, 0.83–1.17), processed meats (1.02, 0.86–1.21) and fish (1.10, 95% CI 0.93–1.29). We also found no associations between meat mutagen intakes and endometrial cancer. Our findings do not support an association between meat or fish intakes or meat mutagens and endometrial cancer.
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影响因子：
8.8
作者：
通讯作者：
--
影响因子：
3.8
作者：
Cantwell, M;Mittl, B;Sinha, R
通讯作者：
Sinha, R
影响因子：
24.5
作者：
Voutsinas J;Wilkens LR;Franke A;Vogt TM;Yokochi LA;Decker R;Le Marchand L
通讯作者：
Le Marchand L
影响因子：
2.3
作者：
Littman, AJ;Beresford, SAA;White, E
通讯作者：
White, E
影响因子：
2.3
作者：
Bandera, Elisa V.;Kushi, Lawrence H.;McCullough, Marjorie L.
通讯作者：
McCullough, Marjorie L.