Conjugated linoleic acid supplementation in humans—metabolic effects
Conjugated linoleic acid supplementation in humans—metabolic effects
复制标题
补充共轭亚油酸对人体的代谢影响
作者：
A. Smedman;B. Vessby
补充共轭亚油酸（CLA）在实验动物中诱导许多生理效应，包括降低体脂含量、减少主动脉脂质沉积和改善血脂谱。迄今为止，关于CLA对人体影响的对照试验很少。本研究的目的是评估健康人补充CLA对人体测量和代谢变量以及对血脂和血小板的脂肪酸组成的影响。53名年龄在23-63岁的健康男女，以双盲的方式被随机分配到补充CLA（4.2 g/d）或等量的橄榄油，在12周内。CLA治疗组的体脂比例降低（-3.8%，P<0.001），与对照组相比有显著差异（P=0.050）。体重、体重指数和矢状腹径无变化。两组间血清脂蛋白、非酯化脂肪酸、血浆胰岛素、血糖或纤溶酶原激活物抑制剂1（派-1）无显著差异。在CLA组中，血清脂质和血小板中硬脂酸、二十二碳四烯酸和二十二碳五烯酸的比例增加，而棕榈酸、油酸和二高γ-亚麻酸的比例减少，导致估计的Δ-6和Δ-9减少，Δ-5去饱和酶活性增加。这些结果表明，补充CLA可以降低人体脂肪的比例，CLA影响脂肪酸代谢。未观察到对体重、血脂、葡萄糖代谢或派-1的影响。
Supplementation with conjugated linoleic acid (CLA) induces a number of physiological effects in experimental animals, including reduced body fat content, decreased aortic lipid deposition, and improved serum lipid profile. Controlled trials on the effects of CLA in humans have hitherto been scarce. The aim of this study was to evaluate the effects of supplementation with CLA in healthy humans on anthropometric and metabolic variables and on the fatty acid composition of serum lipids and thrombocytes. Fifty-three healthy men and women, aged 23–63 yr, were randomly assigned to supplementation with CLA (4.2 g/d) or the same amount of olive oil during 12 wk in a double-blind fashion. The proportion of body fat decreased (−3.8%, P<0.001) in the CLA-treated group, with a significant difference from the control group (P=0.050). Body weight, body mass index, and sagittal abdominal diameter were unchanged. There were no major differences between the groups in serum lipoproteins, nonesterified fatty acids, plasma insulin, blood glucose, or plasminogen activator inhibitor 1 (PAI-1). In the CLA group the proportions of stearic, docosatetraenoic, and docosapentaenoic acids increased in serum lipids and thrombocytes, while proportions of palmitic, oleic, and dihomoγ-linolenic acids decreased, causing a decrease of the estimated Δ-6 and Δ-9 and an increase in the Δ-5 desaturase activities. These results suggest that supplementation with CLA may reduce the proportion of body fat in humans and that CLA affects fatty acid metabolism. No effects on body weight, serum lipids, glucose metabolism, or PAI-1 were seen.
DOI：
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发表时间：
1997
期刊：
Artery
影响因子：
--
作者：
R. Nicolosi;E. Rogers;D. Kritchevsky;J. Scimeca;P. Huth
通讯作者：
R. Nicolosi;E. Rogers;D. Kritchevsky;J. Scimeca;P. Huth
影响因子：
4.7
作者：
Banni, S;Angioni, E;Ip, C
通讯作者：
Ip, C
DOI：
10.1161/01.atv.13.2.162
发表时间：
1993-02-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
FOLSOM, AR;QAMHIEH, HT;WU, KK
通讯作者：
WU, KK