Deaths attributable to carbapenem-resistant Enterobacteriaceae infections.
Deaths attributable to carbapenem-resistant Enterobacteriaceae infections.
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DOI：
10.3201/eid2007.121004
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发表时间：
2014-07
影响因子：
11.8
通讯作者：
Vardakas KZ
中科院分区：
文献类型：
--
作者：
Falagas ME;Tansarli GS;Karageorgopoulos DE;Vardakas KZ
在7项研究中，发生率范围为26%至44%;在2项研究中，发生率分别为-3%和-4%。我们通过使用2012年4月9日之前发表的世界各地的研究，评估了碳青霉烯类耐药肠杆菌科的死亡人数。归因性死亡定义为碳青霉烯类耐药感染患者和碳青霉烯类敏感感染患者之间全因死亡的差异。在线数据库进行了搜索，数据进行了定性合成和汇总的荟萃分析。9项研究符合纳入标准：6项回顾性病例对照研究，2项回顾性队列研究和1项前瞻性队列研究。肺炎克雷伯菌是8项研究中的致病病原体;菌血症是5项研究中唯一的感染。我们计算出，7项研究中26%-44%的死亡可归因于碳青霉烯类耐药，在2项研究中，包括菌血症和其他感染，-3%和-4%的死亡可归因于碳青霉烯类耐药。汇总结果显示，碳青霉烯类耐药感染患者的死亡人数显著较高，并且可归因于碳青霉烯类耐药的死亡人数相当可观。
In 7 studies, rates ranged from 26% to 44%; in 2 studies, rates were −3% and −4%, respectively. We evaluated the number of deaths attributable to carbapenem-resistant Enterobacteriaceae by using studies from around the world published before April 9, 2012. Attributable death was defined as the difference in all-cause deaths between patients with carbapenem-resistant infections and those with carbapenem-susceptible infections. Online databases were searched, and data were qualitatively synthesized and pooled in a metaanalysis. Nine studies met inclusion criteria: 6 retrospective case–control studies, 2 retrospective cohort studies, and 1 prospective cohort study. Klebsiella pneumoniae was the causative pathogen in 8 studies; bacteremia was the only infection in 5 studies. We calculated that 26%–44% of deaths in 7 studies were attributable to carbapenem resistance, and in 2 studies, which included bacteremia and other infections, −3% and −4% of deaths were attributable to carbapenem resistance. Pooled outcomes showed that the number of deaths was significantly higher in patients with carbapenem-resistant infections and that the number of deaths attributable to carbapenem resistance is considerable.
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影响因子：
4.9
作者：
Cuzon, Gaelle;Ouanich, Jocelyne;Nordmann, Patrice
通讯作者：
Nordmann, Patrice
影响因子：
4.9
作者：
Endimiani, Andrea;Carias, Lenore L.;Bonomo, Robert A.
通讯作者：
Bonomo, Robert A.
DOI：
10.1016/j.jmii.2010.06.001
发表时间：
2011-04-01
影响因子：
7.4
作者：
Chang, Hong-Jyun;Hsu, Po-Chang;Lee, Ming-Hsun
通讯作者：
Lee, Ming-Hsun
影响因子：
4.5
作者：
Gasink LB;Edelstein PH;Lautenbach E;Synnestvedt M;Fishman NO
通讯作者：
Fishman NO
影响因子：
5.2
作者：
Pournaras, Spyros;Protonotariou, Efthimia;Sofianou, Danai
通讯作者：
Sofianou, Danai